FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040289008> ?p ?o ?g. }

• W2040289008 abstract "We previously reported that pertussis toxin-sensitive GTP-binding protein is involved in prostaglandin F2 alpha (PGF2 alpha)-induced phosphoinositide (PI) hydrolysis in osteoblast-like MC3T3-E1 cells [Miwa et al. (1990): Biochem Biophys Res Commun 171:1229-1235]. In the present study, we investigated the mechanism of PGF2 alpha-induced Ca2+ influx in MC3T3-E1 cells. PGF2 alpha-induced formation of total inositol phosphates (IPs) was markedly reduced by the depletion of extracellular Ca2+ with EGTA. On the other hand, the depletion of extracellular Ca2+ had little effect on PGF2 alpha-induced inositol 1,4,5-trisphosphate formation. PGF2 alpha stimulated 45Ca2+ influx dose dependently, attaining a maximum effect at 10 nM. Dose of PGF2 alpha above 10 nM caused less than maximal stimulation. Genistein, an inhibitor of protein tyrosine kinase, which by itself had little effect on 45Ca2+ influx, significantly suppressed the PGF2 alpha-induced 45Ca2+ influx in a dose-dependent manner in the range between 1 micrograms/ml and 0.1 mg/ml. Sodium orthovanadate, an inhibitor of protein tyrosine phosphatases, enhanced the PGF2 alpha-induced 45Ca2+ influx. Genistein also suppressed the PGF2 alpha-induced total IPs formation dose dependently in the range between 1 micrograms/ml and 0.1 mg/ml. However, it had little effect on the PGF2 alpha-induced inositol 1,4,5-trisphosphate formation. The pretreatment with pertussis toxin had little effect on the PGF2 alpha-induced 45Ca2+ influx. These results strongly suggest that PGF2 alpha stimulates Ca2+ mobilization from extracellular space and PI hydrolysis via independent pathways in osteoblast-like cells, and the PGF2 alpha-induced Ca2+ influx is regulated by protein tyrosine kinase, resulting in the promotion of PI hydrolysis." @default.
• W2040289008 created "2016-06-24" @default.
• W2040289008 creator A5050087202 @default.
• W2040289008 creator A5056821899 @default.
• W2040289008 creator A5057449137 @default.
• W2040289008 creator A5083502334 @default.
• W2040289008 date "1994-04-01" @default.
• W2040289008 modified "2023-09-26" @default.
• W2040289008 title "Effect of prostaglandin F2α on Ca2+ influx in osteoblast-like cells: Function of tyrosine kinase" @default.
• W2040289008 cites W1656644300 @default.
• W2040289008 cites W1802980406 @default.
• W2040289008 cites W1856590789 @default.
• W2040289008 cites W1904321711 @default.
• W2040289008 cites W1991027949 @default.
• W2040289008 cites W1991861396 @default.
• W2040289008 cites W1997093700 @default.
• W2040289008 cites W1998104311 @default.
• W2040289008 cites W2020257412 @default.
• W2040289008 cites W2023363801 @default.
• W2040289008 cites W2044163708 @default.
• W2040289008 cites W2056739808 @default.
• W2040289008 cites W2061037159 @default.
• W2040289008 cites W2068596665 @default.
• W2040289008 cites W2084152511 @default.
• W2040289008 cites W2086524338 @default.
• W2040289008 cites W2090402759 @default.
• W2040289008 cites W2094944495 @default.
• W2040289008 cites W2104161119 @default.
• W2040289008 cites W2128118061 @default.
• W2040289008 cites W2154523224 @default.
• W2040289008 cites W2164123016 @default.
• W2040289008 cites W277000647 @default.
• W2040289008 cites W3102875255 @default.
• W2040289008 doi "https://doi.org/10.1002/jcb.240540416" @default.
• W2040289008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8014198" @default.
• W2040289008 hasPublicationYear "1994" @default.
• W2040289008 type Work @default.
• W2040289008 sameAs 2040289008 @default.
• W2040289008 citedByCount "18" @default.
• W2040289008 crossrefType "journal-article" @default.
• W2040289008 hasAuthorship W2040289008A5050087202 @default.
• W2040289008 hasAuthorship W2040289008A5056821899 @default.
• W2040289008 hasAuthorship W2040289008A5057449137 @default.
• W2040289008 hasAuthorship W2040289008A5083502334 @default.
• W2040289008 hasConcept C126322002 @default.
• W2040289008 hasConcept C134018914 @default.
• W2040289008 hasConcept C150109051 @default.
• W2040289008 hasConcept C159110408 @default.
• W2040289008 hasConcept C170493617 @default.
• W2040289008 hasConcept C184235292 @default.
• W2040289008 hasConcept C185592680 @default.
• W2040289008 hasConcept C2775944032 @default.
• W2040289008 hasConcept C2777427919 @default.
• W2040289008 hasConcept C2778298627 @default.
• W2040289008 hasConcept C2778618036 @default.
• W2040289008 hasConcept C2780664492 @default.
• W2040289008 hasConcept C2781387506 @default.
• W2040289008 hasConcept C28406088 @default.
• W2040289008 hasConcept C49453240 @default.
• W2040289008 hasConcept C49773422 @default.
• W2040289008 hasConcept C55493867 @default.
• W2040289008 hasConcept C62478195 @default.
• W2040289008 hasConcept C64943373 @default.
• W2040289008 hasConcept C71924100 @default.
• W2040289008 hasConcept C80631254 @default.
• W2040289008 hasConcept C86803240 @default.
• W2040289008 hasConcept C97029542 @default.
• W2040289008 hasConceptScore W2040289008C126322002 @default.
• W2040289008 hasConceptScore W2040289008C134018914 @default.
• W2040289008 hasConceptScore W2040289008C150109051 @default.
• W2040289008 hasConceptScore W2040289008C159110408 @default.
• W2040289008 hasConceptScore W2040289008C170493617 @default.
• W2040289008 hasConceptScore W2040289008C184235292 @default.
• W2040289008 hasConceptScore W2040289008C185592680 @default.
• W2040289008 hasConceptScore W2040289008C2775944032 @default.
• W2040289008 hasConceptScore W2040289008C2777427919 @default.
• W2040289008 hasConceptScore W2040289008C2778298627 @default.
• W2040289008 hasConceptScore W2040289008C2778618036 @default.
• W2040289008 hasConceptScore W2040289008C2780664492 @default.
• W2040289008 hasConceptScore W2040289008C2781387506 @default.
• W2040289008 hasConceptScore W2040289008C28406088 @default.
• W2040289008 hasConceptScore W2040289008C49453240 @default.
• W2040289008 hasConceptScore W2040289008C49773422 @default.
• W2040289008 hasConceptScore W2040289008C55493867 @default.
• W2040289008 hasConceptScore W2040289008C62478195 @default.
• W2040289008 hasConceptScore W2040289008C64943373 @default.
• W2040289008 hasConceptScore W2040289008C71924100 @default.
• W2040289008 hasConceptScore W2040289008C80631254 @default.
• W2040289008 hasConceptScore W2040289008C86803240 @default.
• W2040289008 hasConceptScore W2040289008C97029542 @default.
• W2040289008 hasLocation W20402890081 @default.
• W2040289008 hasLocation W20402890082 @default.
• W2040289008 hasOpenAccess W2040289008 @default.
• W2040289008 hasPrimaryLocation W20402890081 @default.
• W2040289008 hasRelatedWork W1659953295 @default.
• W2040289008 hasRelatedWork W1980464838 @default.
• W2040289008 hasRelatedWork W1985199551 @default.
• W2040289008 hasRelatedWork W1990561187 @default.
• W2040289008 hasRelatedWork W2010677283 @default.
• W2040289008 hasRelatedWork W2035997992 @default.

• next