FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040293283> ?p ?o ?g. }

• W2040293283 endingPage "e7218" @default.
• W2040293283 startingPage "e7218" @default.
• W2040293283 abstract "Treatment strategies for the highly invasive brain tumor, glioblastoma multiforme, require that cells which have invaded into the surrounding brain be specifically targeted. The inherent tumor-tropism of neural stem cells (NSCs) to primary and invasive tumor foci can be exploited to deliver therapeutics to invasive brain tumor cells in humans. Use of the strategy of converting prodrug to drug via therapeutic transgenes delivered by immortalized therapeutic NSC lines have shown efficacy in animal models. Thus therapeutic NSCs are being proposed for use in human brain tumor clinical trials. In the context of NSC-based therapies, MRI can be used both to non-invasively follow dynamic spatio-temporal patterns of the NSC tumor targeting allowing for the optimization of treatment strategies and to assess efficacy of the therapy. Iron-labeling of cells allows their presence to be visualized and tracked by MRI. Thus we aimed to iron-label therapeutic NSCs without affecting their cellular physiology using a method likely to gain United States Federal Drug Administration (FDA) approval.For human use, the characteristics of therapeutic Neural Stem Cells must be clearly defined with any pertubation to the cell including iron labeling requiring reanalysis of cellular physiology. Here, we studied the effect of iron-loading of the therapeutic NSCs, with ferumoxide-protamine sulfate complex (FE-Pro) on viability, proliferation, migratory properties and transgene expression, when compared to non-labeled cells. FE-Pro labeled NSCs were imaged by MRI at tumor sites, after intracranial administration into the hemisphere contralateral to the tumor, in an orthotopic human glioma xenograft mouse model.FE-Pro labeled NSCs retain their proliferative status, tumor tropism, and maintain stem cell character, while allowing in vivo cellular MRI tracking at 7 Tesla, to monitor their real-time migration and distribution at brain tumor sites. Of significance, this work directly supports the use of FE-Pro-labeled NSCs for real-time tracking in the clinical trial under development: A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically modified Neural Stem Cells Expressing Escherichia coli Cytosine Deaminase for Treatment of Recurrent High-Grade Gliomas." @default.
• W2040293283 created "2016-06-24" @default.
• W2040293283 creator A5018750805 @default.
• W2040293283 creator A5024296685 @default.
• W2040293283 creator A5030599987 @default.
• W2040293283 creator A5038297827 @default.
• W2040293283 creator A5040109906 @default.
• W2040293283 creator A5042684673 @default.
• W2040293283 creator A5067225889 @default.
• W2040293283 creator A5068645990 @default.
• W2040293283 creator A5075597662 @default.
• W2040293283 creator A5081967247 @default.
• W2040293283 creator A5068907064 @default.
• W2040293283 creator A5084791896 @default.
• W2040293283 date "2009-09-29" @default.
• W2040293283 modified "2023-10-09" @default.
• W2040293283 title "Iron Labeling and Pre-Clinical MRI Visualization of Therapeutic Human Neural Stem Cells in a Murine Glioma Model" @default.
• W2040293283 cites W1570839422 @default.
• W2040293283 cites W1936342032 @default.
• W2040293283 cites W1964639578 @default.
• W2040293283 cites W1965735982 @default.
• W2040293283 cites W1977530922 @default.
• W2040293283 cites W1980441719 @default.
• W2040293283 cites W1980860710 @default.
• W2040293283 cites W1982580798 @default.
• W2040293283 cites W1984232298 @default.
• W2040293283 cites W1984715217 @default.
• W2040293283 cites W1987899329 @default.
• W2040293283 cites W1990900025 @default.
• W2040293283 cites W1995049782 @default.
• W2040293283 cites W1995968681 @default.
• W2040293283 cites W2000331662 @default.
• W2040293283 cites W2000929915 @default.
• W2040293283 cites W2002809939 @default.
• W2040293283 cites W2004055904 @default.
• W2040293283 cites W2018831921 @default.
• W2040293283 cites W2019207535 @default.
• W2040293283 cites W2024030330 @default.
• W2040293283 cites W2025817925 @default.
• W2040293283 cites W2027542963 @default.
• W2040293283 cites W2031894890 @default.
• W2040293283 cites W2035238560 @default.
• W2040293283 cites W2037375753 @default.
• W2040293283 cites W2041745928 @default.
• W2040293283 cites W2046701925 @default.
• W2040293283 cites W2052106839 @default.
• W2040293283 cites W2067978197 @default.
• W2040293283 cites W2075862824 @default.
• W2040293283 cites W2080759640 @default.
• W2040293283 cites W2085850984 @default.
• W2040293283 cites W2085999292 @default.
• W2040293283 cites W2088454377 @default.
• W2040293283 cites W2088903302 @default.
• W2040293283 cites W2093667448 @default.
• W2040293283 cites W2097196308 @default.
• W2040293283 cites W2099886521 @default.
• W2040293283 cites W2101097858 @default.
• W2040293283 cites W2117049363 @default.
• W2040293283 cites W2118331929 @default.
• W2040293283 cites W2118344648 @default.
• W2040293283 cites W2121045793 @default.
• W2040293283 cites W2121699071 @default.
• W2040293283 cites W2127771136 @default.
• W2040293283 cites W2135212691 @default.
• W2040293283 cites W2135540789 @default.
• W2040293283 cites W2141516981 @default.
• W2040293283 cites W2142089995 @default.
• W2040293283 cites W2144522348 @default.
• W2040293283 cites W2163465346 @default.
• W2040293283 cites W2168432509 @default.
• W2040293283 cites W3189093243 @default.
• W2040293283 cites W4233423789 @default.
• W2040293283 doi "https://doi.org/10.1371/journal.pone.0007218" @default.
• W2040293283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2746284" @default.
• W2040293283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19787043" @default.
• W2040293283 hasPublicationYear "2009" @default.
• W2040293283 type Work @default.
• W2040293283 sameAs 2040293283 @default.
• W2040293283 citedByCount "80" @default.
• W2040293283 countsByYear W20402932832012 @default.
• W2040293283 countsByYear W20402932832013 @default.
• W2040293283 countsByYear W20402932832014 @default.
• W2040293283 countsByYear W20402932832015 @default.
• W2040293283 countsByYear W20402932832016 @default.
• W2040293283 countsByYear W20402932832017 @default.
• W2040293283 countsByYear W20402932832018 @default.
• W2040293283 countsByYear W20402932832019 @default.
• W2040293283 countsByYear W20402932832020 @default.
• W2040293283 countsByYear W20402932832021 @default.
• W2040293283 crossrefType "journal-article" @default.
• W2040293283 hasAuthorship W2040293283A5018750805 @default.
• W2040293283 hasAuthorship W2040293283A5024296685 @default.
• W2040293283 hasAuthorship W2040293283A5030599987 @default.
• W2040293283 hasAuthorship W2040293283A5038297827 @default.
• W2040293283 hasAuthorship W2040293283A5040109906 @default.
• W2040293283 hasAuthorship W2040293283A5042684673 @default.
• W2040293283 hasAuthorship W2040293283A5067225889 @default.
• W2040293283 hasAuthorship W2040293283A5068645990 @default.

• next