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• W2040293417 abstract "To evaluate vascular endothelial-cell functioning in placentas with gestosis, using the monoclonal antibody to cadherin 5.The extra-cellular moiety of cadherin 5 was transfected into L-cells to enable us to examine their cell-adhesion activity. The expression of cadherin 5 was evaluated in human umbilical-vein endothelial cells and in placentas with gestosis by immunostaining using the anti-cadherin 5 antibody. A microspectrophotometric study also was conducted of the placentas with gestosis.We determined the total base sequence for cadherin 5 and found that it is homologous with a known cadherin but is a new, unique clone. Cadherin 5 has cell-adhesion activity and is expressed in endothelial cells at the cell-adhesion surface. The expression of cadherin 5 in endothelial cells took place in the placentas with gestosis, but to a lesser extent than in normal placental endothelial cells.The reduced expression of cadherin 5 in placentas with gestosis suggests that endothelial cell functioning is impaired in placentas with gestosis. Cadherin 5 in endothelial cells might influence placental functions and fetal development." @default.
• W2040293417 created "2016-06-24" @default.
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• W2040293417 date "1998-12-01" @default.
• W2040293417 modified "2023-09-26" @default.
• W2040293417 title "An Immunohistochemical Study of Cadherin 5 (VE-cadherin) in Vascular Endothelial Cells in Placentas with Gestosis" @default.
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• W2040293417 doi "https://doi.org/10.1111/j.1447-0756.1998.tb00112.x" @default.
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