FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040294470> ?p ?o ?g. }

• W2040294470 endingPage "329" @default.
• W2040294470 startingPage "321" @default.
• W2040294470 abstract "We have recently demonstrated that co-administration of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) with the reversible monoamine oxidase type A (MAO-A) inhibitor moclobemide at an ambient temperature of 22 °C significantly increases striatal 5-HT outflow and 5-HT-mediated behaviors. In the present study, using microdialysis, we examined the effects of co-administration of MDMA or para-methoxyamphetamine (PMA) with moclobemide on striatal 5-HT outflow at the elevated ambient temperatures of 30 °C. Samples were collected every 30 min for 4 h and analyzed by high-performance liquid chromatography assay with electrochemical detection (HPLC-ED). 5-HT-mediated effects on body temperature and behavior were also recorded. Rats were treated with either saline or 20 mg/kg (i.p.) moclobemide, followed by 10 mg/kg (i.p.) MDMA, 10 mg/kg (i.p.) PMA or saline 60 min later. Both MDMA and PMA produced significant increases in 5-HT outflow (370% peak and 309% peak, respectively, P<0.05). MDMA and PMA significantly increased body temperature (+2.0 °C and +2.1 °C, respectively, P<0.01) and drug-related behaviors (P<0.05). When MDMA or PMA was co-administered with moclobemide, additional significant increases were seen in 5-HT outflow (850% peak, P<0.01 and 1450% peak, P<0.001, respectively) and only MDMA showed additional significant increase in body temperature (+5.0 °C, P<0.001). No additional increases were seen in behavioral activity. When moclobemide was co-administered with MDMA, sustained increases in body temperature were recorded that were significantly higher than with MDMA alone and such increases were not observed in our previous study at normal room temperature. Our results suggest greater risk of MDMA-induced adverse effects on body temperature regulation, compared with PMA, when used in combination with moclobemide at elevated ambient temperatures." @default.
• W2040294470 created "2016-06-24" @default.
• W2040294470 creator A5031984682 @default.
• W2040294470 creator A5042861005 @default.
• W2040294470 creator A5083995452 @default.
• W2040294470 date "2007-04-01" @default.
• W2040294470 modified "2023-10-11" @default.
• W2040294470 title "The effects of co-administration of 3,4-methylenedioxymethamphetamine (“ecstasy”) or para-methoxyamphetamine and moclobemide at elevated ambient temperatures on striatal 5-HT, body temperature and behavior in rats" @default.
• W2040294470 cites W114941116 @default.
• W2040294470 cites W1826326337 @default.
• W2040294470 cites W1905166601 @default.
• W2040294470 cites W1925106232 @default.
• W2040294470 cites W1960526592 @default.
• W2040294470 cites W1970690567 @default.
• W2040294470 cites W1974249867 @default.
• W2040294470 cites W1993036354 @default.
• W2040294470 cites W1996238145 @default.
• W2040294470 cites W1997306238 @default.
• W2040294470 cites W2000574341 @default.
• W2040294470 cites W2002412029 @default.
• W2040294470 cites W2003069133 @default.
• W2040294470 cites W2004895078 @default.
• W2040294470 cites W2017375285 @default.
• W2040294470 cites W2029633501 @default.
• W2040294470 cites W2030808521 @default.
• W2040294470 cites W2034110682 @default.
• W2040294470 cites W2035759859 @default.
• W2040294470 cites W2036570302 @default.
• W2040294470 cites W2044165548 @default.
• W2040294470 cites W2047258794 @default.
• W2040294470 cites W2047820731 @default.
• W2040294470 cites W2049280393 @default.
• W2040294470 cites W2055627955 @default.
• W2040294470 cites W2056628198 @default.
• W2040294470 cites W2059360851 @default.
• W2040294470 cites W2059551625 @default.
• W2040294470 cites W2061489773 @default.
• W2040294470 cites W2067602580 @default.
• W2040294470 cites W2071419870 @default.
• W2040294470 cites W2073494415 @default.
• W2040294470 cites W2077909659 @default.
• W2040294470 cites W2082609266 @default.
• W2040294470 cites W2082669257 @default.
• W2040294470 cites W2084035469 @default.
• W2040294470 cites W2088737294 @default.
• W2040294470 cites W2094206945 @default.
• W2040294470 cites W2099704738 @default.
• W2040294470 cites W2115752255 @default.
• W2040294470 cites W2124137436 @default.
• W2040294470 cites W2148562084 @default.
• W2040294470 cites W2151818435 @default.
• W2040294470 cites W2151881662 @default.
• W2040294470 cites W2152250921 @default.
• W2040294470 cites W2168021940 @default.
• W2040294470 cites W2168659851 @default.
• W2040294470 cites W2329445637 @default.
• W2040294470 cites W49253821 @default.
• W2040294470 doi "https://doi.org/10.1016/j.neuroscience.2007.01.012" @default.
• W2040294470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17306465" @default.
• W2040294470 hasPublicationYear "2007" @default.
• W2040294470 type Work @default.
• W2040294470 sameAs 2040294470 @default.
• W2040294470 citedByCount "25" @default.
• W2040294470 countsByYear W20402944702012 @default.
• W2040294470 countsByYear W20402944702014 @default.
• W2040294470 countsByYear W20402944702015 @default.
• W2040294470 countsByYear W20402944702016 @default.
• W2040294470 countsByYear W20402944702017 @default.
• W2040294470 countsByYear W20402944702018 @default.
• W2040294470 countsByYear W20402944702019 @default.
• W2040294470 countsByYear W20402944702020 @default.
• W2040294470 countsByYear W20402944702021 @default.
• W2040294470 countsByYear W20402944702023 @default.
• W2040294470 crossrefType "journal-article" @default.
• W2040294470 hasAuthorship W2040294470A5031984682 @default.
• W2040294470 hasAuthorship W2040294470A5042861005 @default.
• W2040294470 hasAuthorship W2040294470A5083995452 @default.
• W2040294470 hasConcept C118552586 @default.
• W2040294470 hasConcept C134018914 @default.
• W2040294470 hasConcept C185592680 @default.
• W2040294470 hasConcept C2777397205 @default.
• W2040294470 hasConcept C2779177272 @default.
• W2040294470 hasConcept C2779488553 @default.
• W2040294470 hasConcept C2780237459 @default.
• W2040294470 hasConcept C2780876324 @default.
• W2040294470 hasConcept C2781161787 @default.
• W2040294470 hasConcept C28406088 @default.
• W2040294470 hasConcept C50156730 @default.
• W2040294470 hasConcept C55493867 @default.
• W2040294470 hasConcept C71924100 @default.
• W2040294470 hasConcept C98274493 @default.
• W2040294470 hasConceptScore W2040294470C118552586 @default.
• W2040294470 hasConceptScore W2040294470C134018914 @default.
• W2040294470 hasConceptScore W2040294470C185592680 @default.
• W2040294470 hasConceptScore W2040294470C2777397205 @default.
• W2040294470 hasConceptScore W2040294470C2779177272 @default.
• W2040294470 hasConceptScore W2040294470C2779488553 @default.
• W2040294470 hasConceptScore W2040294470C2780237459 @default.

• next