FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040298230> ?p ?o ?g. }

• W2040298230 abstract "Untreated Parkinson's disease (FD) patients typically demonstrate an upregulation in striatal D(2) receptor binding. Reduced D(2) binding is found in levodopa-treated patients with a fluctuating response to this drug. Using PET and (11)C-raclopride, we determined striatal:background uptake ratios to provide a measure of D(2) receptor binding in 10 untreated, newly diagnosed PD patients who were treated subsequently with levodopa for 1 yr. At baseline, we found increased striatal D(2) receptor uptake ratios in patients (3.89) in comparison to normal controls (3.22; p < 0.02). Furthermore, the ratio between caudate and putamen D(2) uptake was significantly reduced in patients (0.86 vs. 0.98 in normals, p < 0.01). Patients were subsequently randomized to treatment with either SINEMET((R)) (300 mg of levodopa/d) or SINEMET((R)) CR (400 mg of levodopa/d). Patients in both groups received similar symptomatic benefit following treatment, and none developed motor fluctuations. All patients were rescanned after 6 months of treatment. There were no significant differences in striatal (or caudate and putamen considered singly) raclopride binding between the first and 6 month post-treatment scans. Similarly, there were no significant differences between pre- and 6 month post-treatment scans on the basis of levodopa preparations. Patients were subsequently treated with the other Sinemet preparation for another 6 month period before rescanning. Again, no differences in raclopride binding were found compared to pre-treatment or between type of levodopa preparation. We conclude that there is no evidence for downregulation of D(2) receptor binding after 1 yr of low-dose levodopa therapy in patients who receive symptomatic benefit without motor fluctuations, regardless of type of preparation. Follow-up of such individuals may permit determination of when and in what context D(2) receptor downregulation occurs." @default.
• W2040298230 created "2016-06-24" @default.
• W2040298230 creator A5009044500 @default.
• W2040298230 creator A5013933146 @default.
• W2040298230 creator A5015382924 @default.
• W2040298230 creator A5062031696 @default.
• W2040298230 creator A5085058399 @default.
• W2040298230 date "1997-01-01" @default.
• W2040298230 modified "2023-10-11" @default.
• W2040298230 title "Positron emission tomography (PET) measurements of striatal D2 receptors in untreated Parkinson's disease patients with follow-up after 6 and 12 months' treatment with SINEMET® or SINEMET® CR" @default.
• W2040298230 cites W1821065636 @default.
• W2040298230 cites W18319520 @default.
• W2040298230 cites W189164303 @default.
• W2040298230 cites W1980884630 @default.
• W2040298230 cites W1981609060 @default.
• W2040298230 cites W1985050254 @default.
• W2040298230 cites W2002624259 @default.
• W2040298230 cites W2011415448 @default.
• W2040298230 cites W2017607874 @default.
• W2040298230 cites W2028167448 @default.
• W2040298230 cites W2033936242 @default.
• W2040298230 cites W2051824831 @default.
• W2040298230 cites W2054658543 @default.
• W2040298230 cites W2055281234 @default.
• W2040298230 cites W2064996887 @default.
• W2040298230 cites W2070191357 @default.
• W2040298230 cites W2084340599 @default.
• W2040298230 cites W2086701255 @default.
• W2040298230 cites W2094332834 @default.
• W2040298230 cites W2104004822 @default.
• W2040298230 cites W2119933341 @default.
• W2040298230 cites W2136888049 @default.
• W2040298230 cites W2147702204 @default.
• W2040298230 cites W2159081727 @default.
• W2040298230 cites W2165908461 @default.
• W2040298230 cites W2411876550 @default.
• W2040298230 cites W2417837354 @default.
• W2040298230 cites W2419176067 @default.
• W2040298230 cites W90233223 @default.
• W2040298230 cites W99762335 @default.
• W2040298230 doi "https://doi.org/10.1016/s1353-8020(96)00038-7" @default.
• W2040298230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18591053" @default.
• W2040298230 hasPublicationYear "1997" @default.
• W2040298230 type Work @default.
• W2040298230 sameAs 2040298230 @default.
• W2040298230 citedByCount "4" @default.
• W2040298230 crossrefType "journal-article" @default.
• W2040298230 hasAuthorship W2040298230A5009044500 @default.
• W2040298230 hasAuthorship W2040298230A5013933146 @default.
• W2040298230 hasAuthorship W2040298230A5015382924 @default.
• W2040298230 hasAuthorship W2040298230A5062031696 @default.
• W2040298230 hasAuthorship W2040298230A5085058399 @default.
• W2040298230 hasConcept C126322002 @default.
• W2040298230 hasConcept C15744967 @default.
• W2040298230 hasConcept C2779134260 @default.
• W2040298230 hasConcept C2779714222 @default.
• W2040298230 hasConcept C2779734285 @default.
• W2040298230 hasConcept C2780062018 @default.
• W2040298230 hasConcept C2780304432 @default.
• W2040298230 hasConcept C2781069445 @default.
• W2040298230 hasConcept C2781423529 @default.
• W2040298230 hasConcept C2989005 @default.
• W2040298230 hasConcept C513476851 @default.
• W2040298230 hasConcept C71924100 @default.
• W2040298230 hasConcept C90924648 @default.
• W2040298230 hasConceptScore W2040298230C126322002 @default.
• W2040298230 hasConceptScore W2040298230C15744967 @default.
• W2040298230 hasConceptScore W2040298230C2779134260 @default.
• W2040298230 hasConceptScore W2040298230C2779714222 @default.
• W2040298230 hasConceptScore W2040298230C2779734285 @default.
• W2040298230 hasConceptScore W2040298230C2780062018 @default.
• W2040298230 hasConceptScore W2040298230C2780304432 @default.
• W2040298230 hasConceptScore W2040298230C2781069445 @default.
• W2040298230 hasConceptScore W2040298230C2781423529 @default.
• W2040298230 hasConceptScore W2040298230C2989005 @default.
• W2040298230 hasConceptScore W2040298230C513476851 @default.
• W2040298230 hasConceptScore W2040298230C71924100 @default.
• W2040298230 hasConceptScore W2040298230C90924648 @default.
• W2040298230 hasLocation W20402982301 @default.
• W2040298230 hasLocation W20402982302 @default.
• W2040298230 hasOpenAccess W2040298230 @default.
• W2040298230 hasPrimaryLocation W20402982301 @default.
• W2040298230 hasRelatedWork W1973335238 @default.
• W2040298230 hasRelatedWork W2027496660 @default.
• W2040298230 hasRelatedWork W2041817703 @default.
• W2040298230 hasRelatedWork W2057255875 @default.
• W2040298230 hasRelatedWork W2092132787 @default.
• W2040298230 hasRelatedWork W2143065841 @default.
• W2040298230 hasRelatedWork W2171531937 @default.
• W2040298230 hasRelatedWork W2350626807 @default.
• W2040298230 hasRelatedWork W2352228855 @default.
• W2040298230 hasRelatedWork W2366888095 @default.
• W2040298230 hasRelatedWork W2376682382 @default.
• W2040298230 hasRelatedWork W2386221658 @default.
• W2040298230 hasRelatedWork W2415473410 @default.
• W2040298230 hasRelatedWork W2419086852 @default.
• W2040298230 hasRelatedWork W2604395256 @default.
• W2040298230 hasRelatedWork W2892842164 @default.
• W2040298230 hasRelatedWork W2905927491 @default.
• W2040298230 hasRelatedWork W2999219594 @default.

• next