FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040298958> ?p ?o ?g. }

• W2040298958 endingPage "595" @default.
• W2040298958 startingPage "587" @default.
• W2040298958 abstract "The present phase I trial was planned to assess the maximum tolerated dose, the dose-limiting toxicity and the pharmacokinetics of bendamustine hydrochloride in a once every 3 weeks schedule, and to recommend a safe dose for future phase II studies. Included were patients with refractory solid tumors. Bendamustine hydrochloride was administered as a short intravenous infusion over 30 min. The starting dose was defined at 160 mg/m2 and dose escalation used increments of 20 mg/m2. Plasma and urine samples were analyzed using validated high-pressure liquid chromatography/fluorescence assays. Twenty-six patients (14 men, 12 women) were enrolled for the study. At 280 mg/m2, one out of four patients developed a thrombocytopenia grade 4, two experienced grade 3 fatigue and three experienced cardiac toxicity (grade 2). The latter toxicity was considered dose limiting also and further dose escalation was stopped. Plasma pharmacokinetics parameters of bendamustine hydrochloride and its metabolites were assessed in 15 patients. Mean pharmacokinetic parameters of bendamustine hydrochloride were a tmax of 32.3 min, a t1/2 of 37.8 min, a volume of distribution of 14.2 l/m2 and a clearance of 287.8 ml/min/m2. No dose dependency of bendamustine hydrochloride was observed within the used dose range. The metabolites comprised only 23% of the overall area under the concentration–time curve. The maximum tolerated dose of bendamustine hydrochloride on day 1 q 3 weeks is 280 mg/m2. Fatigue and cardiac toxicity were dose limiting. The plasma pharmacokinetics data of bendamustine and its metabolites were in accordance with previous reports. The recommended dose for future trials is 260 mg/m2 every 3 weeks." @default.
• W2040298958 created "2016-06-24" @default.
• W2040298958 creator A5002953291 @default.
• W2040298958 creator A5007067879 @default.
• W2040298958 creator A5024160619 @default.
• W2040298958 creator A5057841250 @default.
• W2040298958 creator A5059919011 @default.
• W2040298958 creator A5059965685 @default.
• W2040298958 creator A5067174039 @default.
• W2040298958 date "2007-06-01" @default.
• W2040298958 modified "2023-09-26" @default.
• W2040298958 title "A phase I study of bendamustine hydrochloride administered once every 3 weeks in patients with solid tumors" @default.
• W2040298958 cites W1584622450 @default.
• W2040298958 cites W1964540536 @default.
• W2040298958 cites W1976127594 @default.
• W2040298958 cites W1992839401 @default.
• W2040298958 cites W2009899170 @default.
• W2040298958 cites W2036333108 @default.
• W2040298958 cites W2038989389 @default.
• W2040298958 cites W2054811026 @default.
• W2040298958 cites W2067291268 @default.
• W2040298958 cites W2074533771 @default.
• W2040298958 cites W2078603533 @default.
• W2040298958 cites W2090947517 @default.
• W2040298958 cites W2099611691 @default.
• W2040298958 cites W2122451479 @default.
• W2040298958 cites W2330136896 @default.
• W2040298958 cites W3142198163 @default.
• W2040298958 cites W3189831118 @default.
• W2040298958 cites W4232322475 @default.
• W2040298958 cites W4241695609 @default.
• W2040298958 cites W4251235745 @default.
• W2040298958 doi "https://doi.org/10.1097/cad.0b013e3280149eb1" @default.
• W2040298958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17414628" @default.
• W2040298958 hasPublicationYear "2007" @default.
• W2040298958 type Work @default.
• W2040298958 sameAs 2040298958 @default.
• W2040298958 citedByCount "33" @default.
• W2040298958 countsByYear W20402989582012 @default.
• W2040298958 countsByYear W20402989582013 @default.
• W2040298958 countsByYear W20402989582014 @default.
• W2040298958 countsByYear W20402989582015 @default.
• W2040298958 countsByYear W20402989582016 @default.
• W2040298958 countsByYear W20402989582017 @default.
• W2040298958 countsByYear W20402989582018 @default.
• W2040298958 countsByYear W20402989582019 @default.
• W2040298958 countsByYear W20402989582020 @default.
• W2040298958 countsByYear W20402989582022 @default.
• W2040298958 crossrefType "journal-article" @default.
• W2040298958 hasAuthorship W2040298958A5002953291 @default.
• W2040298958 hasAuthorship W2040298958A5007067879 @default.
• W2040298958 hasAuthorship W2040298958A5024160619 @default.
• W2040298958 hasAuthorship W2040298958A5057841250 @default.
• W2040298958 hasAuthorship W2040298958A5059919011 @default.
• W2040298958 hasAuthorship W2040298958A5059965685 @default.
• W2040298958 hasAuthorship W2040298958A5067174039 @default.
• W2040298958 hasConcept C112705442 @default.
• W2040298958 hasConcept C126322002 @default.
• W2040298958 hasConcept C2779338263 @default.
• W2040298958 hasConcept C2780653079 @default.
• W2040298958 hasConcept C2781442060 @default.
• W2040298958 hasConcept C29730261 @default.
• W2040298958 hasConcept C71924100 @default.
• W2040298958 hasConcept C98274493 @default.
• W2040298958 hasConceptScore W2040298958C112705442 @default.
• W2040298958 hasConceptScore W2040298958C126322002 @default.
• W2040298958 hasConceptScore W2040298958C2779338263 @default.
• W2040298958 hasConceptScore W2040298958C2780653079 @default.
• W2040298958 hasConceptScore W2040298958C2781442060 @default.
• W2040298958 hasConceptScore W2040298958C29730261 @default.
• W2040298958 hasConceptScore W2040298958C71924100 @default.
• W2040298958 hasConceptScore W2040298958C98274493 @default.
• W2040298958 hasIssue "5" @default.
• W2040298958 hasLocation W20402989581 @default.
• W2040298958 hasLocation W20402989582 @default.
• W2040298958 hasOpenAccess W2040298958 @default.
• W2040298958 hasPrimaryLocation W20402989581 @default.
• W2040298958 hasRelatedWork W1982282930 @default.
• W2040298958 hasRelatedWork W2141289501 @default.
• W2040298958 hasRelatedWork W2343559465 @default.
• W2040298958 hasRelatedWork W2594910449 @default.
• W2040298958 hasRelatedWork W2606334551 @default.
• W2040298958 hasRelatedWork W2774225352 @default.
• W2040298958 hasRelatedWork W2960553615 @default.
• W2040298958 hasRelatedWork W2991030316 @default.
• W2040298958 hasRelatedWork W3043458966 @default.
• W2040298958 hasRelatedWork W4364376666 @default.
• W2040298958 hasVolume "18" @default.
• W2040298958 isParatext "false" @default.
• W2040298958 isRetracted "false" @default.
• W2040298958 magId "2040298958" @default.
• W2040298958 workType "article" @default.