FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040299410> ?p ?o ?g. }

• W2040299410 endingPage "206" @default.
• W2040299410 startingPage "201" @default.
• W2040299410 abstract "Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Several major pathogens have resisted traditional vaccine development, although vulnerable epitopes targeted by neutralizing antibodies have been identified for several such cases. Hence, new vaccine design methods to induce epitope-specific neutralizing antibodies are needed. Here we show, with a neutralization epitope from respiratory syncytial virus, that computational protein design can generate small, thermally and conformationally stable protein scaffolds that accurately mimic the viral epitope structure and induce potent neutralizing antibodies. These scaffolds represent promising leads for the research and development of a human respiratory syncytial virus vaccine needed to protect infants, young children and the elderly. More generally, the results provide proof of principle for epitope-focused and scaffold-based vaccine design, and encourage the evaluation and further development of these strategies for a variety of other vaccine targets, including antigenically highly variable pathogens such as human immunodeficiency virus and influenza. Computational protein design methods are used to generate new candidates for a human respiratory syncytial virus (RSV) vaccine; artificial protein scaffolds that mimic the structure of a RSV epitope are shown to induce RSV-specific neutralizing antibodies in macaques. William Schief and colleagues explore computational protein design methods to generate novel candidates for a human respiratory syncytial virus (RSV) vaccine. Artificial protein scaffolds that mimic the structure of an RSV epitope or antigenic determinant are shown to induce RSV-neutralizing antibodies in macaques. The protein design method used here, that builds a protein around a functional motif in order to stabilize the conformation of that motif, could have broad application in vaccine development." @default.
• W2040299410 created "2016-06-24" @default.
• W2040299410 creator A5005976336 @default.
• W2040299410 creator A5007228090 @default.
• W2040299410 creator A5015718808 @default.
• W2040299410 creator A5016461260 @default.
• W2040299410 creator A5016866868 @default.
• W2040299410 creator A5017333832 @default.
• W2040299410 creator A5021608465 @default.
• W2040299410 creator A5026114666 @default.
• W2040299410 creator A5030551505 @default.
• W2040299410 creator A5036954555 @default.
• W2040299410 creator A5037123473 @default.
• W2040299410 creator A5038912051 @default.
• W2040299410 creator A5040838563 @default.
• W2040299410 creator A5043176904 @default.
• W2040299410 creator A5046971682 @default.
• W2040299410 creator A5048716954 @default.
• W2040299410 creator A5050272964 @default.
• W2040299410 creator A5053192926 @default.
• W2040299410 creator A5056542055 @default.
• W2040299410 creator A5060919860 @default.
• W2040299410 creator A5064867080 @default.
• W2040299410 creator A5064936359 @default.
• W2040299410 creator A5067186373 @default.
• W2040299410 creator A5072849746 @default.
• W2040299410 creator A5079598732 @default.
• W2040299410 creator A5080655703 @default.
• W2040299410 creator A5088859925 @default.
• W2040299410 date "2014-02-05" @default.
• W2040299410 modified "2023-10-16" @default.
• W2040299410 title "Proof of principle for epitope-focused vaccine design" @default.
• W2040299410 cites W1548178570 @default.
• W2040299410 cites W1672638796 @default.
• W2040299410 cites W1967865769 @default.
• W2040299410 cites W1969644422 @default.
• W2040299410 cites W1976948056 @default.
• W2040299410 cites W1993017721 @default.
• W2040299410 cites W2016019047 @default.
• W2040299410 cites W2016453064 @default.
• W2040299410 cites W2020055244 @default.
• W2040299410 cites W2025141560 @default.
• W2040299410 cites W2030947664 @default.
• W2040299410 cites W2040477035 @default.
• W2040299410 cites W2050957868 @default.
• W2040299410 cites W2052277371 @default.
• W2040299410 cites W2054392131 @default.
• W2040299410 cites W2082176639 @default.
• W2040299410 cites W2083637922 @default.
• W2040299410 cites W2093529351 @default.
• W2040299410 cites W2094048920 @default.
• W2040299410 cites W2097950056 @default.
• W2040299410 cites W2105225614 @default.
• W2040299410 cites W2109339916 @default.
• W2040299410 cites W2117608592 @default.
• W2040299410 cites W2121627241 @default.
• W2040299410 cites W2124150826 @default.
• W2040299410 cites W2125065061 @default.
• W2040299410 cites W2131222241 @default.
• W2040299410 cites W2131859684 @default.
• W2040299410 cites W2137633461 @default.
• W2040299410 cites W2141501895 @default.
• W2040299410 cites W2152048324 @default.
• W2040299410 cites W2156381249 @default.
• W2040299410 cites W2166740197 @default.
• W2040299410 cites W2169821755 @default.
• W2040299410 cites W2201713963 @default.
• W2040299410 cites W2244674613 @default.
• W2040299410 cites W2319653158 @default.
• W2040299410 doi "https://doi.org/10.1038/nature12966" @default.
• W2040299410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4260937" @default.
• W2040299410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24499818" @default.
• W2040299410 hasPublicationYear "2014" @default.
• W2040299410 type Work @default.
• W2040299410 sameAs 2040299410 @default.
• W2040299410 citedByCount "429" @default.
• W2040299410 countsByYear W20402994102014 @default.
• W2040299410 countsByYear W20402994102015 @default.
• W2040299410 countsByYear W20402994102016 @default.
• W2040299410 countsByYear W20402994102017 @default.
• W2040299410 countsByYear W20402994102018 @default.
• W2040299410 countsByYear W20402994102019 @default.
• W2040299410 countsByYear W20402994102020 @default.
• W2040299410 countsByYear W20402994102021 @default.
• W2040299410 countsByYear W20402994102022 @default.
• W2040299410 countsByYear W20402994102023 @default.
• W2040299410 crossrefType "journal-article" @default.
• W2040299410 hasAuthorship W2040299410A5005976336 @default.
• W2040299410 hasAuthorship W2040299410A5007228090 @default.
• W2040299410 hasAuthorship W2040299410A5015718808 @default.
• W2040299410 hasAuthorship W2040299410A5016461260 @default.
• W2040299410 hasAuthorship W2040299410A5016866868 @default.
• W2040299410 hasAuthorship W2040299410A5017333832 @default.
• W2040299410 hasAuthorship W2040299410A5021608465 @default.
• W2040299410 hasAuthorship W2040299410A5026114666 @default.
• W2040299410 hasAuthorship W2040299410A5030551505 @default.
• W2040299410 hasAuthorship W2040299410A5036954555 @default.
• W2040299410 hasAuthorship W2040299410A5037123473 @default.

• next