FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040300337> ?p ?o ?g. }

• W2040300337 endingPage "1830" @default.
• W2040300337 startingPage "1817" @default.
• W2040300337 abstract "Polytherapy, based on the rational combining of antiepileptic drugs (AEDs), is required for patients with drug-resistant epilepsy. In such cases, the combinations of AEDs usually offer a significant enhancement of their protective effects against seizures. There has appeared a hypothesis that combining two AEDs, influencing the same neurotransmitter system, results in the potentialization of their anticonvulsant effects. For corroborating this hypothesis, a pharmacological character of interaction between tiagabine (TGB) and gabapentin (GBP)—two novel AEDs affecting the GABA-ergic system, in the maximal electroshock seizure threshold (MEST)-test in mice was evaluated. TGB at the dose of 4 mg/kg and GBP at 75 mg/kg significantly raised the electroconvulsive threshold. Further, using the isobolographic calculations, TGB was coadministered with GBP at three fixed-ratios (1 : 3, 1 : 1, and 3 : 1) of their respective protective drug doses. All examined combinations of TGB with GBP exerted supra-additive (synergistic) interactions against MEST-induced seizures in mice. The interaction index, describing the strength and magnitude of interaction, ranged between 0.25 and 0.50 indicating supra-additivity. Adverse (neurotoxic) effects were evaluated in the chimney (motor performance) and the step-through, light–dark passive avoidance (long-term memory) tests in mice. The examined combinations of TGB with GBP did not affect the motor coordination, except for the fixed-ratio of 1 : 1, at which significant impairment of motor performance was observed. Moreover, all combinations selectively impaired the acquisition of the task in the passive avoidance test, having no impact on consolidation and retrieval in the long-term memory test. The pain threshold test revealed that the observed disturbances in the passive avoidance testing resulted presumably from the antinociceptive activity of these AEDs in combinations. After lengthening the exposing time to the direct current stimulus in the passive avoidance test from 2 to 6 s, the acquisition of the task, in animals receiving the combinations of TGB and GBP was not impaired. Neither the plasma, nor brain concentrations of GBP were affected by TGB application, so pharmacokinetic events that might negatively influence the observed effects are not probable. Results of this study clearly indicate that the activation of the same neurotransmitter system (GABA-ergic) leads to a synergistic interaction. The pain threshold test is a very good paradigm for screening the antinociceptive properties of AEDs, which may disturb the long-term memory testing in animals. Combinations of TGB with GBP (very promising from a preclinical point of view) should be clinically verified for elaborating the most effective treatment regimen in patients with intractable seizures." @default.
• W2040300337 created "2016-06-24" @default.
• W2040300337 creator A5009737999 @default.
• W2040300337 creator A5078348855 @default.
• W2040300337 creator A5082905482 @default.
• W2040300337 creator A5088764698 @default.
• W2040300337 date "2003-05-23" @default.
• W2040300337 modified "2023-10-17" @default.
• W2040300337 title "Tiagabine Synergistically Interacts with Gabapentin in the Electroconvulsive Threshold Test in Mice" @default.
• W2040300337 cites W1514118911 @default.
• W2040300337 cites W15975779 @default.
• W2040300337 cites W1964491424 @default.
• W2040300337 cites W1964809668 @default.
• W2040300337 cites W1965450907 @default.
• W2040300337 cites W1966837740 @default.
• W2040300337 cites W1967715258 @default.
• W2040300337 cites W1967876125 @default.
• W2040300337 cites W1967881343 @default.
• W2040300337 cites W1968465698 @default.
• W2040300337 cites W1968543162 @default.
• W2040300337 cites W1969032718 @default.
• W2040300337 cites W1971815377 @default.
• W2040300337 cites W1974861738 @default.
• W2040300337 cites W1975101207 @default.
• W2040300337 cites W1976354860 @default.
• W2040300337 cites W1977906243 @default.
• W2040300337 cites W1978283158 @default.
• W2040300337 cites W1983021024 @default.
• W2040300337 cites W1987721729 @default.
• W2040300337 cites W1988584892 @default.
• W2040300337 cites W1994799351 @default.
• W2040300337 cites W2004361024 @default.
• W2040300337 cites W2009317359 @default.
• W2040300337 cites W2009841830 @default.
• W2040300337 cites W2010819337 @default.
• W2040300337 cites W2013757953 @default.
• W2040300337 cites W2013833587 @default.
• W2040300337 cites W2014182056 @default.
• W2040300337 cites W2014670473 @default.
• W2040300337 cites W2015176438 @default.
• W2040300337 cites W2016679698 @default.
• W2040300337 cites W2018452063 @default.
• W2040300337 cites W2019719664 @default.
• W2040300337 cites W2025114653 @default.
• W2040300337 cites W2029462182 @default.
• W2040300337 cites W2029783753 @default.
• W2040300337 cites W2030035902 @default.
• W2040300337 cites W2030254120 @default.
• W2040300337 cites W2031325622 @default.
• W2040300337 cites W2031773542 @default.
• W2040300337 cites W2035291193 @default.
• W2040300337 cites W2035495751 @default.
• W2040300337 cites W2037997999 @default.
• W2040300337 cites W2039982019 @default.
• W2040300337 cites W2041907686 @default.
• W2040300337 cites W2043286801 @default.
• W2040300337 cites W2046323117 @default.
• W2040300337 cites W2050287406 @default.
• W2040300337 cites W2050503366 @default.
• W2040300337 cites W2052822287 @default.
• W2040300337 cites W2054066188 @default.
• W2040300337 cites W2054656910 @default.
• W2040300337 cites W2055681053 @default.
• W2040300337 cites W2055799067 @default.
• W2040300337 cites W2057926710 @default.
• W2040300337 cites W2057983296 @default.
• W2040300337 cites W2059480812 @default.
• W2040300337 cites W2065174084 @default.
• W2040300337 cites W2067249871 @default.
• W2040300337 cites W2067310840 @default.
• W2040300337 cites W2071158876 @default.
• W2040300337 cites W2071934749 @default.
• W2040300337 cites W2074834196 @default.
• W2040300337 cites W2075157564 @default.
• W2040300337 cites W2076344852 @default.
• W2040300337 cites W2076430158 @default.
• W2040300337 cites W2077123622 @default.
• W2040300337 cites W2078553244 @default.
• W2040300337 cites W2080762052 @default.
• W2040300337 cites W2084508142 @default.
• W2040300337 cites W2085083777 @default.
• W2040300337 cites W2088002520 @default.
• W2040300337 cites W2088569461 @default.
• W2040300337 cites W2089126407 @default.
• W2040300337 cites W2091745180 @default.
• W2040300337 cites W2092254107 @default.
• W2040300337 cites W2093148987 @default.
• W2040300337 cites W2102368782 @default.
• W2040300337 cites W2103289578 @default.
• W2040300337 cites W2113011586 @default.
• W2040300337 cites W2117821503 @default.
• W2040300337 cites W2125832312 @default.
• W2040300337 cites W2126814491 @default.
• W2040300337 cites W2158562453 @default.
• W2040300337 cites W4233691345 @default.
• W2040300337 cites W67404996 @default.
• W2040300337 cites W86645420 @default.
• W2040300337 doi "https://doi.org/10.1038/sj.npp.1300243" @default.

• next