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• W2040302170 abstract "Intracellular recordings were made from neurons of the guinea pig submucosal plexus and the effects of substance P and the substance P analogue [d-Arg1, d-Pro2, d-Trp7,9,Leu11]substance P were examined. Substance P (20–200 nM) depolarized all submucosal neurons; these depolarizations were shown to be due to a decrease in the resting (or “leak”) potassium conductance of the membrane. In approximately 50% of the 46 neurons tested, superfusion with [d-Arg1, d-Pro2, d-Trp7,9,Leu11]substance P (0.2–20 μM) produced a dose-dependent membrane hyperpolarization. This hyperpolarization was prevented by theα2-adrenoceptor antagonist idazoxan (300 nM) or by concentrations of cobalt which abolished all spontaneous and evoked synaptic potentials, indicating that it resulted from release of noradrenaline from sympathetic nerve terminals. [d-Arg1, d-Pro2, d-Trp7,9,Leu11]substance P depressed the amplitude of the three synaptic potentials recorded from submucosal neurons; the concentrations that caused 50% of the maximal inhibition of the fast excitatory postsynaptic potential, the inhibitory postsynaptic potential and slow excitatory postsynaptic potential were 40 μM, 600 nM and 20 μM, respectively. When idazoxan was present, the substance P analogue was less effective in depressing the amplitudes of the fast and slow excitatory synaptic potentials suggesting that much of its presynaptic inhibition also resulted from release of noradrenaline. These results provide evidence that [d-Arg1, d-Pro2, d-Trp7,9,Leu11]substance P releases noradrenaline from sympathetic nerves in the submucosal plexus. One effect of this is a membrane hyperpolarization; another is a presynaptic inhibition of transmitter release. These actions much limit the usefulness of this “substance P antagonist” in efforts to show that synaptic potentials, such as the slow excitatory synaptic potential, are mediated by substance P." @default.
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• W2040302170 date "1987-01-01" @default.
• W2040302170 modified "2023-10-12" @default.
• W2040302170 title "Observations on the actions of substance P and [d-Arg1, d-Pro2, d-Trp7,9,Leu11]substance P on single neurons of the guinea pig submucous plexus" @default.
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• W2040302170 doi "https://doi.org/10.1016/0306-4522(87)90011-x" @default.
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