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- W2040304403 abstract "Publisher Summary This chapter focuses primarily on recent reports relating to issues that remain unresolved in the field of multidrug-resistance and on developments that have come to the forefront in the past few years. After a brief overview of mdr genes and P-glycoprotein, (Pgp) activity, it discusses the clinical relevance of the human MDR1 gene and Pgp, the mechanism by which Pgp confers drug-resistance and the regulation of MDR1 gene activity in normal and cancer cells. The chapter briefly reviews what is known about other cellular mechanisms for conferring resistance to mdr-related drugs and the clinical aspect of mdr by discussing prospects for overcoming multidrug-resistance in light of what is now known about its mechanisms of action. MDR1 or mdr has been used generically to refer to mammalian genes functional in conferring multidrug-resistance." @default.
- W2040304403 created "2016-06-24" @default.
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- W2040304403 date "2010-08-04" @default.
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- W2040304403 title "ChemInform Abstract: Multidrug Resistance of Cancer Cells" @default.
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- W2040304403 doi "https://doi.org/10.1002/chin.199642292" @default.
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