Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040308935> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2040308935 endingPage "707" @default.
- W2040308935 startingPage "703" @default.
- W2040308935 abstract "Since the discovery of the Vitamin D receptor (VDR) in mammary cells, the role of the Vitamin D signaling pathway in normal glandular function and in breast cancer has been extensively explored. In vitro studies have demonstrated that the VDR ligand, 1,25(OH)(2)D(3), modulates key proteins involved in signaling proliferation, differentiation and survival of normal mammary epithelial cells. Anti-proliferative and pro-differentiating effects of 1,25(OH)(2)D(3) have also been observed in VDR positive breast cancer cells, indicating that transformation per se does not abolish Vitamin D signaling. However, many breast cancer cell lines are less sensitive to 1,25(OH)(2)D(3) than normal mammary epithelial cells. Reduced sensitivity to 1,25(OH)(2)D(3) has been linked to alterations in Vitamin D metabolizing enzymes as well as down regulation of VDR expression or function. In this report, we describe results from a proteomics screening approach used to search for proteins involved in dictating sensitivity or resistance to Vitamin D mediated apoptosis in breast cancer cells. Several proteins not previously linked to 1,25(OH)(2)D(3) signaling were identified with this approach, and a distinct subset of proteins was linked to 1,25(OH)(2)D(3) resistance. Follow-up studies to determine the relevance of these proteins to Vitamin D signaling in general are in progress." @default.
- W2040308935 created "2016-06-24" @default.
- W2040308935 creator A5033449102 @default.
- W2040308935 creator A5064207380 @default.
- W2040308935 date "2007-03-01" @default.
- W2040308935 modified "2023-09-23" @default.
- W2040308935 title "Identification of novel mediators of Vitamin D signaling and 1,25(OH)2D3 resistance in mammary cells" @default.
- W2040308935 cites W1257832338 @default.
- W2040308935 cites W1505801452 @default.
- W2040308935 cites W1509478882 @default.
- W2040308935 cites W156119405 @default.
- W2040308935 cites W1969847161 @default.
- W2040308935 cites W1980025879 @default.
- W2040308935 cites W1980992126 @default.
- W2040308935 cites W1981199654 @default.
- W2040308935 cites W1982886830 @default.
- W2040308935 cites W1986240597 @default.
- W2040308935 cites W1988827270 @default.
- W2040308935 cites W1990411057 @default.
- W2040308935 cites W2012127625 @default.
- W2040308935 cites W2026194974 @default.
- W2040308935 cites W2046085802 @default.
- W2040308935 cites W2057591273 @default.
- W2040308935 cites W2059937375 @default.
- W2040308935 cites W2064866491 @default.
- W2040308935 cites W2070004921 @default.
- W2040308935 cites W2072419218 @default.
- W2040308935 cites W2084198387 @default.
- W2040308935 cites W2087798593 @default.
- W2040308935 cites W2090630654 @default.
- W2040308935 cites W2091312049 @default.
- W2040308935 cites W2100982243 @default.
- W2040308935 cites W2105121049 @default.
- W2040308935 cites W2108352304 @default.
- W2040308935 cites W2109858742 @default.
- W2040308935 cites W2117968225 @default.
- W2040308935 cites W2126718035 @default.
- W2040308935 cites W2138153315 @default.
- W2040308935 cites W2157735691 @default.
- W2040308935 cites W2275785652 @default.
- W2040308935 cites W4233946009 @default.
- W2040308935 doi "https://doi.org/10.1016/j.jsbmb.2006.12.061" @default.
- W2040308935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1885398" @default.
- W2040308935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17254776" @default.
- W2040308935 hasPublicationYear "2007" @default.
- W2040308935 type Work @default.
- W2040308935 sameAs 2040308935 @default.
- W2040308935 citedByCount "33" @default.
- W2040308935 countsByYear W20403089352012 @default.
- W2040308935 countsByYear W20403089352013 @default.
- W2040308935 countsByYear W20403089352014 @default.
- W2040308935 countsByYear W20403089352015 @default.
- W2040308935 countsByYear W20403089352017 @default.
- W2040308935 countsByYear W20403089352018 @default.
- W2040308935 crossrefType "journal-article" @default.
- W2040308935 hasAuthorship W2040308935A5033449102 @default.
- W2040308935 hasAuthorship W2040308935A5064207380 @default.
- W2040308935 hasBestOaLocation W20403089352 @default.
- W2040308935 hasConcept C124490489 @default.
- W2040308935 hasConcept C134018914 @default.
- W2040308935 hasConcept C179639408 @default.
- W2040308935 hasConcept C31033888 @default.
- W2040308935 hasConcept C502942594 @default.
- W2040308935 hasConcept C62478195 @default.
- W2040308935 hasConcept C86803240 @default.
- W2040308935 hasConcept C95444343 @default.
- W2040308935 hasConceptScore W2040308935C124490489 @default.
- W2040308935 hasConceptScore W2040308935C134018914 @default.
- W2040308935 hasConceptScore W2040308935C179639408 @default.
- W2040308935 hasConceptScore W2040308935C31033888 @default.
- W2040308935 hasConceptScore W2040308935C502942594 @default.
- W2040308935 hasConceptScore W2040308935C62478195 @default.
- W2040308935 hasConceptScore W2040308935C86803240 @default.
- W2040308935 hasConceptScore W2040308935C95444343 @default.
- W2040308935 hasIssue "3-5" @default.
- W2040308935 hasLocation W20403089351 @default.
- W2040308935 hasLocation W20403089352 @default.
- W2040308935 hasLocation W20403089353 @default.
- W2040308935 hasLocation W20403089354 @default.
- W2040308935 hasOpenAccess W2040308935 @default.
- W2040308935 hasPrimaryLocation W20403089351 @default.
- W2040308935 hasRelatedWork W1982933346 @default.
- W2040308935 hasRelatedWork W2000797165 @default.
- W2040308935 hasRelatedWork W2011197845 @default.
- W2040308935 hasRelatedWork W2037727994 @default.
- W2040308935 hasRelatedWork W2083873811 @default.
- W2040308935 hasRelatedWork W2594452790 @default.
- W2040308935 hasRelatedWork W4210971708 @default.
- W2040308935 hasRelatedWork W4226217405 @default.
- W2040308935 hasRelatedWork W4313248744 @default.
- W2040308935 hasRelatedWork W87938621 @default.
- W2040308935 hasVolume "103" @default.
- W2040308935 isParatext "false" @default.
- W2040308935 isRetracted "false" @default.
- W2040308935 magId "2040308935" @default.
- W2040308935 workType "article" @default.