FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040309970> ?p ?o ?g. }

• W2040309970 endingPage "14" @default.
• W2040309970 startingPage "9" @default.
• W2040309970 abstract "Summary Autoantibodies to insulin (IAA) are one of the first markers of the autoimmune process leading to type 1 diabetes (T1D). While other autoantibodies in T1D have been studied extensively, relatively little is known about IAA and their binding specificities, especially after insulin treatment is initiated. We hypothesize that insulin antibodies (IA) that develop upon initiation of insulin treatment differ in their epitope specificities from IAA. We analysed insulin antibody binding specificities in longitudinal samples of T1D patients (n = 49). Samples were taken at clinical diagnosis of disease and after insulin treatment was initiated. The epitope specificities were analysed using recombinant Fab (rFab) derived from insulin-specific monoclonal antibodies AE9D6 and CG7C7. Binding of radiolabelled insulin by samples taken at onset of the disease was significantly reduced in the presence of rFab CG7C7 and AE9D6. rFab AE9D6 competed sera binding to insulin significantly better than rFab CG7C7 (P = 0·02). Binding to the AE9D6-defined epitope in the initial sample was correlated inversely with age at onset (P = 0·005). The binding to the AE9D6-defined epitope increased significantly (P &lt; 0·0001) after 3 months of insulin treatment. Binding to the CG7C7-defined epitope did not change during the analysed period of 12 months. We conclude that epitopes recognized by insulin binding antibodies can be identified using monoclonal insulin-specific rFab as competitors. Using this approach we observed that insulin treatment is accompanied by a change in epitope specificities in the emerging IA." @default.
• W2040309970 created "2016-06-24" @default.
• W2040309970 creator A5006680848 @default.
• W2040309970 creator A5013030521 @default.
• W2040309970 creator A5030709033 @default.
• W2040309970 creator A5031203373 @default.
• W2040309970 creator A5031652759 @default.
• W2040309970 creator A5036401896 @default.
• W2040309970 creator A5081200857 @default.
• W2040309970 date "2006-08-16" @default.
• W2040309970 modified "2023-10-02" @default.
• W2040309970 title "Longitudinal epitope analysis of insulin-binding antibodies in type 1 diabetes" @default.
• W2040309970 cites W106081178 @default.
• W2040309970 cites W1781531090 @default.
• W2040309970 cites W1968278124 @default.
• W2040309970 cites W1973200446 @default.
• W2040309970 cites W1992942784 @default.
• W2040309970 cites W1996624137 @default.
• W2040309970 cites W1997152974 @default.
• W2040309970 cites W2010776016 @default.
• W2040309970 cites W2019400285 @default.
• W2040309970 cites W2034787026 @default.
• W2040309970 cites W2052751274 @default.
• W2040309970 cites W2053387251 @default.
• W2040309970 cites W2059598532 @default.
• W2040309970 cites W2068028236 @default.
• W2040309970 cites W2075267555 @default.
• W2040309970 cites W2075551338 @default.
• W2040309970 cites W2077577428 @default.
• W2040309970 cites W2093902049 @default.
• W2040309970 cites W2106869746 @default.
• W2040309970 cites W2111625815 @default.
• W2040309970 cites W2113093880 @default.
• W2040309970 cites W2117282940 @default.
• W2040309970 cites W2117735514 @default.
• W2040309970 cites W2119654658 @default.
• W2040309970 cites W2123412381 @default.
• W2040309970 cites W2129551653 @default.
• W2040309970 cites W2130957301 @default.
• W2040309970 cites W2158176433 @default.
• W2040309970 cites W2158257115 @default.
• W2040309970 cites W2167845501 @default.
• W2040309970 cites W2334639754 @default.
• W2040309970 cites W2561747152 @default.
• W2040309970 cites W4246356838 @default.
• W2040309970 doi "https://doi.org/10.1111/j.1365-2249.2006.03178.x" @default.
• W2040309970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1809737" @default.
• W2040309970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16968392" @default.
• W2040309970 hasPublicationYear "2006" @default.
• W2040309970 type Work @default.
• W2040309970 sameAs 2040309970 @default.
• W2040309970 citedByCount "12" @default.
• W2040309970 countsByYear W20403099702015 @default.
• W2040309970 countsByYear W20403099702016 @default.
• W2040309970 countsByYear W20403099702017 @default.
• W2040309970 countsByYear W20403099702018 @default.
• W2040309970 countsByYear W20403099702021 @default.
• W2040309970 countsByYear W20403099702023 @default.
• W2040309970 crossrefType "journal-article" @default.
• W2040309970 hasAuthorship W2040309970A5006680848 @default.
• W2040309970 hasAuthorship W2040309970A5013030521 @default.
• W2040309970 hasAuthorship W2040309970A5030709033 @default.
• W2040309970 hasAuthorship W2040309970A5031203373 @default.
• W2040309970 hasAuthorship W2040309970A5031652759 @default.
• W2040309970 hasAuthorship W2040309970A5036401896 @default.
• W2040309970 hasAuthorship W2040309970A5081200857 @default.
• W2040309970 hasBestOaLocation W20403099701 @default.
• W2040309970 hasConcept C126322002 @default.
• W2040309970 hasConcept C134018914 @default.
• W2040309970 hasConcept C159654299 @default.
• W2040309970 hasConcept C163764329 @default.
• W2040309970 hasConcept C163864487 @default.
• W2040309970 hasConcept C195616568 @default.
• W2040309970 hasConcept C203014093 @default.
• W2040309970 hasConcept C2779075594 @default.
• W2040309970 hasConcept C2779306644 @default.
• W2040309970 hasConcept C2781232474 @default.
• W2040309970 hasConcept C2781241564 @default.
• W2040309970 hasConcept C542903549 @default.
• W2040309970 hasConcept C555293320 @default.
• W2040309970 hasConcept C71924100 @default.
• W2040309970 hasConcept C86803240 @default.
• W2040309970 hasConceptScore W2040309970C126322002 @default.
• W2040309970 hasConceptScore W2040309970C134018914 @default.
• W2040309970 hasConceptScore W2040309970C159654299 @default.
• W2040309970 hasConceptScore W2040309970C163764329 @default.
• W2040309970 hasConceptScore W2040309970C163864487 @default.
• W2040309970 hasConceptScore W2040309970C195616568 @default.
• W2040309970 hasConceptScore W2040309970C203014093 @default.
• W2040309970 hasConceptScore W2040309970C2779075594 @default.
• W2040309970 hasConceptScore W2040309970C2779306644 @default.
• W2040309970 hasConceptScore W2040309970C2781232474 @default.
• W2040309970 hasConceptScore W2040309970C2781241564 @default.
• W2040309970 hasConceptScore W2040309970C542903549 @default.
• W2040309970 hasConceptScore W2040309970C555293320 @default.
• W2040309970 hasConceptScore W2040309970C71924100 @default.
• W2040309970 hasConceptScore W2040309970C86803240 @default.
• W2040309970 hasIssue "1" @default.

• next