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- W2040312691 abstract "Significance Using virus-induced gene silencing (VIGS) in wild-type and mutant Arabidopsis , we characterize a novel mechanism associated with the de novo establishment of heritable epigenetic marks in plants. Once established by this novel mechanism, the epigenetic mark is then reinforced by the previously characterized PolIV pathway of RNA-directed DNA methylation. A similar transition from the novel mechanism to the PolIV pathway is likely to explain many epigenetic phenomena in which RNA-directed DNA methylation is established de novo, including transposon silencing and paramutation. A practical benefit of our work is the identification of a mutant plant genotype in which the maintenance mechanism of epigenetic VIGS is reinforced. This genotype would aid the use of epigenetic VIGS for dissection of gene structure and function." @default.
- W2040312691 created "2016-06-24" @default.
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- W2040312691 date "2015-01-05" @default.
- W2040312691 modified "2023-10-16" @default.
- W2040312691 title "Epigenetic transitions leading to heritable, RNA-mediated de novo silencing in <i>Arabidopsis thaliana</i>" @default.
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- W2040312691 doi "https://doi.org/10.1073/pnas.1413053112" @default.
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