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• W2040317364 abstract "The aza-C-nucleosides, Immucillin-H and Immucillin-G, are transition state analogue inhibitors of purine nucleoside phosphorylase, a therapeutic target for the control of T-cell proliferation. Immucillin analogues modified at the 2'-, 3'-, or 5'-positions of the azasugar moiety or at the 6-, 7-, or 8-positions of the deazapurine, as well as methylene-bridged analogues, have been synthesized and tested for their inhibition of human purine nucleoside phosphorylase. All analogues were poorer inhibitors, which reflects the superior capture of transition state features in the parent immucillins." @default.
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• W2040317364 date "2003-06-20" @default.
• W2040317364 modified "2023-09-23" @default.
• W2040317364 title "Exploring Structure−Activity Relationships of Transition State Analogues of Human Purine Nucleoside Phosphorylase" @default.
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• W2040317364 doi "https://doi.org/10.1021/jm030145r" @default.
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