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- W2040321738 abstract "Abstract High-dose valaciclovir at up to 8 g/day has been shown to be effective in prophylaxis against cytomegalovirus (CMV) disease in renal transplant recipients. We report our experience with low-dose valaciclovir prophylaxis of up to 3 g/day, adjusted to creatinine clearance. A group of patients at high risk of developing CMV disease who received prophylaxis were selected as the study group. This included all CMV-positive patients who received antilymphocyte therapy (R +, n=20) and all CMV-negative recipients of CMV-positive organs (D + R−, n=15). D + R− patients receiving antilymphocyte therapy were excluded, as most of the patients in the control group had received ganciclovir prophylaxis. A historical control group was used, which consisted of patients who did not receive prophylaxis. Low-dose valaciclovir prophylaxis resulted in a statistically significant decrease (8.5 vs 37%, P=0.004) in CMV disease in the study group at 6 months. On subgroup analysis the decrease was statistically significant only in the R + group (5 vs 45%, P=0.003), not in the D + R− group (13.3 vs 26.6%, P=0.651). Low-dose valaciclovir prophylaxis seems to be adequate for R + patients receiving antilymphocyte therapy. The role of low-dose valaciclovir prophylaxis needs to be assessed further in a prospective trial." @default.
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- W2040321738 date "2003-10-01" @default.
- W2040321738 modified "2023-09-26" @default.
- W2040321738 title "Low-dose valaciclovir prophylaxis againt cytomegalovirus disease in renal transplant recipients" @default.
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- W2040321738 doi "https://doi.org/10.1111/j.1432-2277.2003.tb00231.x" @default.
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