FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040324906> ?p ?o ?g. }

• W2040324906 endingPage "494" @default.
• W2040324906 startingPage "486" @default.
• W2040324906 abstract "Background and objectives: In asthma, airway smooth muscle cell (ASMC) hyperplasia plays an important role in airway remodelling. Increased expression of matrix metalloproteinases‐9 (MMP‐9), a disintegrin and metalloprotease 33 (ADAM33) in ASMCs are also relevant to asthmatic airway remodelling. 1,25‐dihydroxyvitamin D 3 (1,25‐(OH) 2 D 3 ) has potent antiproliferative properties in vitro in various cell types; however, its role in ASMCs is not well understood. This study investigated the effect of 1,25‐(OH) 2 D 3 on passively sensitized human bronchial (airway) smooth muscle cell (HASMC) proliferation and MMP‐9 and ADAM33 expressions. Methods: The effect of 1,25‐(OH) 2 D 3 on cell proliferation was examined by 3‐(4,5‐dimethylthiazole‐2‐yl)‐2,5‐diphenyltetrazolium‐bromide colorimetry assay; cell cycle analysis by flow cytometry; and immunocytochemical staining for proliferating cell nuclear antigen (PCNA). The expression of MMP‐9 and ADAM33 in HASMCs was investigated by real‐time quantitative PCR and Western Blot analysis. Results: 1,25‐(OH) 2 D 3 effectively suppressed passively sensitized HASMC proliferation, proliferating cell nuclear antigen expression and G 1 /S transition in HASMCs passively sensitized with asthmatic serum. Further analysis showed that 1,25‐(OH) 2 D 3 significantly down‐regulated the expressions of protein for MMP‐9 and ADAM33, as well as their mRNA levels in passively sensitized HASMCs. Conclusions: 1,25‐(OH) 2 D 3 has direct inhibitory effects on passively sensitized HASMCs in vitro , including inhibition of cell proliferation and expression of MMP‐9 and ADAM33, suggesting a possible beneficial role for 1,25‐(OH) 2 D 3 in preventing and treating asthmatic airway remodelling." @default.
• W2040324906 created "2016-06-24" @default.
• W2040324906 creator A5006882142 @default.
• W2040324906 creator A5015474460 @default.
• W2040324906 creator A5009303774 @default.
• W2040324906 date "2007-06-06" @default.
• W2040324906 modified "2023-10-15" @default.
• W2040324906 title "Effect of 1,25-(OH)₂D₃(a vitamin D analogue) on passively sensitized human airway smooth muscle cells" @default.
• W2040324906 cites W1664645310 @default.
• W2040324906 cites W1786542967 @default.
• W2040324906 cites W1854781184 @default.
• W2040324906 cites W1968641373 @default.
• W2040324906 cites W1971662522 @default.
• W2040324906 cites W1982140654 @default.
• W2040324906 cites W1984407952 @default.
• W2040324906 cites W1994590258 @default.
• W2040324906 cites W2018038375 @default.
• W2040324906 cites W2041373197 @default.
• W2040324906 cites W2045404555 @default.
• W2040324906 cites W2049216745 @default.
• W2040324906 cites W2053712921 @default.
• W2040324906 cites W2058731596 @default.
• W2040324906 cites W2059966546 @default.
• W2040324906 cites W2063014521 @default.
• W2040324906 cites W2063425192 @default.
• W2040324906 cites W2070352767 @default.
• W2040324906 cites W2082588666 @default.
• W2040324906 cites W2085465225 @default.
• W2040324906 cites W2096149081 @default.
• W2040324906 cites W2120454419 @default.
• W2040324906 cites W2122908584 @default.
• W2040324906 cites W2126663143 @default.
• W2040324906 cites W2130462780 @default.
• W2040324906 cites W2143371668 @default.
• W2040324906 cites W2154645767 @default.
• W2040324906 cites W2154761796 @default.
• W2040324906 cites W2164360357 @default.
• W2040324906 cites W2170733786 @default.
• W2040324906 cites W4211046201 @default.
• W2040324906 doi "https://doi.org/10.1111/j.1440-1843.2007.01099.x" @default.
• W2040324906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17587413" @default.
• W2040324906 hasPublicationYear "2007" @default.
• W2040324906 type Work @default.
• W2040324906 sameAs 2040324906 @default.
• W2040324906 citedByCount "92" @default.
• W2040324906 countsByYear W20403249062012 @default.
• W2040324906 countsByYear W20403249062013 @default.
• W2040324906 countsByYear W20403249062014 @default.
• W2040324906 countsByYear W20403249062015 @default.
• W2040324906 countsByYear W20403249062016 @default.
• W2040324906 countsByYear W20403249062017 @default.
• W2040324906 countsByYear W20403249062018 @default.
• W2040324906 countsByYear W20403249062019 @default.
• W2040324906 countsByYear W20403249062020 @default.
• W2040324906 countsByYear W20403249062021 @default.
• W2040324906 countsByYear W20403249062022 @default.
• W2040324906 countsByYear W20403249062023 @default.
• W2040324906 crossrefType "journal-article" @default.
• W2040324906 hasAuthorship W2040324906A5006882142 @default.
• W2040324906 hasAuthorship W2040324906A5009303774 @default.
• W2040324906 hasAuthorship W2040324906A5015474460 @default.
• W2040324906 hasBestOaLocation W20403249061 @default.
• W2040324906 hasConcept C109523444 @default.
• W2040324906 hasConcept C121608353 @default.
• W2040324906 hasConcept C126322002 @default.
• W2040324906 hasConcept C134018914 @default.
• W2040324906 hasConcept C1491633281 @default.
• W2040324906 hasConcept C153911025 @default.
• W2040324906 hasConcept C203014093 @default.
• W2040324906 hasConcept C204232928 @default.
• W2040324906 hasConcept C29537977 @default.
• W2040324906 hasConcept C34688535 @default.
• W2040324906 hasConcept C553184892 @default.
• W2040324906 hasConcept C55493867 @default.
• W2040324906 hasConcept C62112901 @default.
• W2040324906 hasConcept C71924100 @default.
• W2040324906 hasConcept C86803240 @default.
• W2040324906 hasConceptScore W2040324906C109523444 @default.
• W2040324906 hasConceptScore W2040324906C121608353 @default.
• W2040324906 hasConceptScore W2040324906C126322002 @default.
• W2040324906 hasConceptScore W2040324906C134018914 @default.
• W2040324906 hasConceptScore W2040324906C1491633281 @default.
• W2040324906 hasConceptScore W2040324906C153911025 @default.
• W2040324906 hasConceptScore W2040324906C203014093 @default.
• W2040324906 hasConceptScore W2040324906C204232928 @default.
• W2040324906 hasConceptScore W2040324906C29537977 @default.
• W2040324906 hasConceptScore W2040324906C34688535 @default.
• W2040324906 hasConceptScore W2040324906C553184892 @default.
• W2040324906 hasConceptScore W2040324906C55493867 @default.
• W2040324906 hasConceptScore W2040324906C62112901 @default.
• W2040324906 hasConceptScore W2040324906C71924100 @default.
• W2040324906 hasConceptScore W2040324906C86803240 @default.
• W2040324906 hasIssue "4" @default.
• W2040324906 hasLocation W20403249061 @default.
• W2040324906 hasLocation W20403249062 @default.
• W2040324906 hasOpenAccess W2040324906 @default.
• W2040324906 hasPrimaryLocation W20403249061 @default.
• W2040324906 hasRelatedWork W1686076540 @default.

• next