FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040327447> ?p ?o ?g. }

• W2040327447 endingPage "4412" @default.
• W2040327447 startingPage "4412" @default.
• W2040327447 abstract "The attachment of immortalized hypothalamic murine neurons onto the surface of an acoustic wave device yields both positive series resonant frequency (fs) and motional resistance (Rm) shifts as opposed to commonly reported negative fs and positive Rm shifts observed for other cell types. These unique shifts have been confirmed by a variety of experiments in order to verify the source and the validity of the signals. These studies involved monitoring responses to solution flow, the absence of serum proteins, the effect of reducing specific cell -surface interactions and the disruption of the neuronal cytoskeleton components. For the adhesion and deposition of neurons, fs and Rm shifts are positively correlated to the amount of adhered neurons on the sensor surface, whereas non-adhered neurons do not produce any significant change in the monitored parameters. In the absence of serum proteins, initial cell adhesion is followed by subsequent cell death and removal from the sensor surface. The presence of the peptide, GRGDS is observed to significantly reduce cell-surface specific interactions compared to the control of SDGRG and this produces fs and Rm responses that are opposite in direction to that observable for cell adhesion. Cytoskeletal studies, using the drugs nocodazole (10μM), colchicine (1μM), cytochalasin B (10μM) and cytochalasin D (2μM) all elicit neuronal responses that are validated by phalloidin actin-filament staining. These results indicate that the responses are associated with a wide range of cellular changes that can be monitored and studied using the acoustic wave method in real time, under optimal physiological conditions." @default.
• W2040327447 created "2016-06-24" @default.
• W2040327447 creator A5009158848 @default.
• W2040327447 creator A5009281074 @default.
• W2040327447 creator A5018943064 @default.
• W2040327447 creator A5041324990 @default.
• W2040327447 creator A5059717484 @default.
• W2040327447 date "2011-01-01" @default.
• W2040327447 modified "2023-09-27" @default.
• W2040327447 title "Interfacial behavior of immortalized hypothalamic mouse neurons detected by acoustic wave propagation" @default.
• W2040327447 cites W1964913810 @default.
• W2040327447 cites W1968013951 @default.
• W2040327447 cites W1972953180 @default.
• W2040327447 cites W1985723851 @default.
• W2040327447 cites W1985770165 @default.
• W2040327447 cites W1986605125 @default.
• W2040327447 cites W1994109845 @default.
• W2040327447 cites W1996931454 @default.
• W2040327447 cites W2001678988 @default.
• W2040327447 cites W2006254525 @default.
• W2040327447 cites W2028852111 @default.
• W2040327447 cites W2033727098 @default.
• W2040327447 cites W2040192992 @default.
• W2040327447 cites W2053694862 @default.
• W2040327447 cites W2055439074 @default.
• W2040327447 cites W2060134703 @default.
• W2040327447 cites W2060904122 @default.
• W2040327447 cites W2064792292 @default.
• W2040327447 cites W2066960489 @default.
• W2040327447 cites W2072776319 @default.
• W2040327447 cites W2075520022 @default.
• W2040327447 cites W2075558783 @default.
• W2040327447 cites W2077779358 @default.
• W2040327447 cites W2078644234 @default.
• W2040327447 cites W2080678112 @default.
• W2040327447 cites W2083673604 @default.
• W2040327447 cites W2089068379 @default.
• W2040327447 cites W2093378019 @default.
• W2040327447 cites W2108765497 @default.
• W2040327447 cites W2110339757 @default.
• W2040327447 cites W2129843226 @default.
• W2040327447 doi "https://doi.org/10.1039/c1an15534b" @default.
• W2040327447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21866285" @default.
• W2040327447 hasPublicationYear "2011" @default.
• W2040327447 type Work @default.
• W2040327447 sameAs 2040327447 @default.
• W2040327447 citedByCount "6" @default.
• W2040327447 countsByYear W20403274472013 @default.
• W2040327447 countsByYear W20403274472014 @default.
• W2040327447 countsByYear W20403274472016 @default.
• W2040327447 countsByYear W20403274472020 @default.
• W2040327447 crossrefType "journal-article" @default.
• W2040327447 hasAuthorship W2040327447A5009158848 @default.
• W2040327447 hasAuthorship W2040327447A5009281074 @default.
• W2040327447 hasAuthorship W2040327447A5018943064 @default.
• W2040327447 hasAuthorship W2040327447A5041324990 @default.
• W2040327447 hasAuthorship W2040327447A5059717484 @default.
• W2040327447 hasConcept C120665830 @default.
• W2040327447 hasConcept C121332964 @default.
• W2040327447 hasConcept C12554922 @default.
• W2040327447 hasConcept C125705527 @default.
• W2040327447 hasConcept C142669718 @default.
• W2040327447 hasConcept C1491633281 @default.
• W2040327447 hasConcept C162954803 @default.
• W2040327447 hasConcept C178790620 @default.
• W2040327447 hasConcept C185592680 @default.
• W2040327447 hasConcept C2775995422 @default.
• W2040327447 hasConcept C2776041460 @default.
• W2040327447 hasConcept C2776861759 @default.
• W2040327447 hasConcept C2779012151 @default.
• W2040327447 hasConcept C2779363559 @default.
• W2040327447 hasConcept C55493867 @default.
• W2040327447 hasConcept C84416704 @default.
• W2040327447 hasConcept C86803240 @default.
• W2040327447 hasConceptScore W2040327447C120665830 @default.
• W2040327447 hasConceptScore W2040327447C121332964 @default.
• W2040327447 hasConceptScore W2040327447C12554922 @default.
• W2040327447 hasConceptScore W2040327447C125705527 @default.
• W2040327447 hasConceptScore W2040327447C142669718 @default.
• W2040327447 hasConceptScore W2040327447C1491633281 @default.
• W2040327447 hasConceptScore W2040327447C162954803 @default.
• W2040327447 hasConceptScore W2040327447C178790620 @default.
• W2040327447 hasConceptScore W2040327447C185592680 @default.
• W2040327447 hasConceptScore W2040327447C2775995422 @default.
• W2040327447 hasConceptScore W2040327447C2776041460 @default.
• W2040327447 hasConceptScore W2040327447C2776861759 @default.
• W2040327447 hasConceptScore W2040327447C2779012151 @default.
• W2040327447 hasConceptScore W2040327447C2779363559 @default.
• W2040327447 hasConceptScore W2040327447C55493867 @default.
• W2040327447 hasConceptScore W2040327447C84416704 @default.
• W2040327447 hasConceptScore W2040327447C86803240 @default.
• W2040327447 hasIssue "21" @default.
• W2040327447 hasLocation W20403274471 @default.
• W2040327447 hasLocation W20403274472 @default.
• W2040327447 hasOpenAccess W2040327447 @default.
• W2040327447 hasPrimaryLocation W20403274471 @default.
• W2040327447 hasRelatedWork W2004952942 @default.
• W2040327447 hasRelatedWork W2040327447 @default.

• next