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- W2040328047 abstract "The physiological role of the platelet-secreted protein thrombospondin (TSP) is poorly understood, although it has been postulated to be involved in platelet aggregation and cellular adhesion. In this report, TSP isolated from human platelets was found to promote, in vitro, the cell-substratum adhesion of a variety of cells, including platelets, melanoma cells, muscle cells, endothelial cells, fibroblasts, and epithelial cells. The adhesion-promoting activity of TSP was species independent, specific, and not due to contamination by fibronectin, vitronectin, laminin, or platelet factor 4. The cell surface receptor for TSP is protein in nature and appears distinct from that for fibronectin." @default.
- W2040328047 created "2016-06-24" @default.
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- W2040328047 date "1987-06-19" @default.
- W2040328047 modified "2023-09-26" @default.
- W2040328047 title "Thrombospondin Promotes Cell-Substratum Adhesion" @default.
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- W2040328047 doi "https://doi.org/10.1126/science.2438772" @default.
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