FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040332457> ?p ?o ?g. }

• W2040332457 abstract "Phosphatidylinositol 3-kinase (PI 3-kinase) has been cloned and characterized in a wide range of organisms. PI 3-kinases are activated by a diversity of extracellular stimuli and are involved in multiple cell processes such as cell proliferation, protein trafficking, cell motility, differentiation, regulation of cytoskeletal structure, and apoptosis. It has recently been shown that PI 3-kinase is a crucial second messenger in the signaling of myogenesis. Two structurally unrelated highly specific inhibitors of PI 3-kinase-wortmannin and LY294002-block the morphological and biochemical differentiation program of different skeletal-muscle cell models. Moreover, L6E9 myoblasts overexpressing a dominant-negative mutant of PI 3-kinase p85 regulatory subunit (Δp85) are unable to differentiate. Furthermore, PI 3-kinase is specifically involved in the insulinlike growth factor (IGF)-dependent myogenic pathway. Indeed, the ability of IGF-I, des-1,3-IGF-I, and IGF-II to promote cell fusion and muscle-specific protein expression is impaired after treatment with PI 3-kinase inhibitors or in cells overexpressing Δp85. The identification of additional key downstream elements of the IGF/PI 3-kinase myogenic cascade is crucial to a detailed understanding of the process of muscle differentiation and may generate new tools for skeletal and cardiac muscle regeneration therapies. (Trends Cardiovasc Med 1997;7:198-202). © 1997, Elsevier Science Inc." @default.
• W2040332457 created "2016-06-24" @default.
• W2040332457 creator A5059581003 @default.
• W2040332457 creator A5080920068 @default.
• W2040332457 date "1997-08-01" @default.
• W2040332457 modified "2023-09-27" @default.
• W2040332457 title "Phosphatidylinositol 3-Kinase in Myogenesis" @default.
• W2040332457 cites W1487365829 @default.
• W2040332457 cites W1490641559 @default.
• W2040332457 cites W1524183923 @default.
• W2040332457 cites W1525061031 @default.
• W2040332457 cites W1529396499 @default.
• W2040332457 cites W1593480031 @default.
• W2040332457 cites W1593806089 @default.
• W2040332457 cites W1595752904 @default.
• W2040332457 cites W1643628872 @default.
• W2040332457 cites W1972527462 @default.
• W2040332457 cites W1973500578 @default.
• W2040332457 cites W1973546377 @default.
• W2040332457 cites W1974543599 @default.
• W2040332457 cites W1979012059 @default.
• W2040332457 cites W1979046428 @default.
• W2040332457 cites W1982274138 @default.
• W2040332457 cites W1994957003 @default.
• W2040332457 cites W2003867300 @default.
• W2040332457 cites W2013131355 @default.
• W2040332457 cites W2020811802 @default.
• W2040332457 cites W2037241011 @default.
• W2040332457 cites W2046286320 @default.
• W2040332457 cites W2055492254 @default.
• W2040332457 cites W2058138221 @default.
• W2040332457 cites W2063117678 @default.
• W2040332457 cites W2070002301 @default.
• W2040332457 cites W2076875187 @default.
• W2040332457 cites W2078718449 @default.
• W2040332457 cites W2085668133 @default.
• W2040332457 cites W2088871209 @default.
• W2040332457 cites W2102476333 @default.
• W2040332457 cites W2103421087 @default.
• W2040332457 cites W2114258437 @default.
• W2040332457 cites W2122043314 @default.
• W2040332457 cites W2129844699 @default.
• W2040332457 cites W2134064618 @default.
• W2040332457 cites W2141608854 @default.
• W2040332457 cites W2144447876 @default.
• W2040332457 cites W2155326275 @default.
• W2040332457 cites W2157189324 @default.
• W2040332457 cites W2159511823 @default.
• W2040332457 cites W2161316513 @default.
• W2040332457 cites W2166300250 @default.
• W2040332457 cites W2287708722 @default.
• W2040332457 doi "https://doi.org/10.1016/s1050-1738(97)00050-9" @default.
• W2040332457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21235885" @default.
• W2040332457 hasPublicationYear "1997" @default.
• W2040332457 type Work @default.
• W2040332457 sameAs 2040332457 @default.
• W2040332457 citedByCount "3" @default.
• W2040332457 crossrefType "journal-article" @default.
• W2040332457 hasAuthorship W2040332457A5059581003 @default.
• W2040332457 hasAuthorship W2040332457A5080920068 @default.
• W2040332457 hasConcept C134018914 @default.
• W2040332457 hasConcept C184235292 @default.
• W2040332457 hasConcept C207200792 @default.
• W2040332457 hasConcept C2778308172 @default.
• W2040332457 hasConcept C2779959927 @default.
• W2040332457 hasConcept C2780610907 @default.
• W2040332457 hasConcept C3763915 @default.
• W2040332457 hasConcept C62478195 @default.
• W2040332457 hasConcept C66417403 @default.
• W2040332457 hasConcept C82495950 @default.
• W2040332457 hasConcept C86803240 @default.
• W2040332457 hasConcept C95444343 @default.
• W2040332457 hasConcept C97029542 @default.
• W2040332457 hasConceptScore W2040332457C134018914 @default.
• W2040332457 hasConceptScore W2040332457C184235292 @default.
• W2040332457 hasConceptScore W2040332457C207200792 @default.
• W2040332457 hasConceptScore W2040332457C2778308172 @default.
• W2040332457 hasConceptScore W2040332457C2779959927 @default.
• W2040332457 hasConceptScore W2040332457C2780610907 @default.
• W2040332457 hasConceptScore W2040332457C3763915 @default.
• W2040332457 hasConceptScore W2040332457C62478195 @default.
• W2040332457 hasConceptScore W2040332457C66417403 @default.
• W2040332457 hasConceptScore W2040332457C82495950 @default.
• W2040332457 hasConceptScore W2040332457C86803240 @default.
• W2040332457 hasConceptScore W2040332457C95444343 @default.
• W2040332457 hasConceptScore W2040332457C97029542 @default.
• W2040332457 hasLocation W20403324571 @default.
• W2040332457 hasLocation W20403324572 @default.
• W2040332457 hasOpenAccess W2040332457 @default.
• W2040332457 hasPrimaryLocation W20403324571 @default.
• W2040332457 hasRelatedWork W1553280517 @default.
• W2040332457 hasRelatedWork W1634157550 @default.
• W2040332457 hasRelatedWork W1970947849 @default.
• W2040332457 hasRelatedWork W1995087657 @default.
• W2040332457 hasRelatedWork W2041502549 @default.
• W2040332457 hasRelatedWork W2047499782 @default.
• W2040332457 hasRelatedWork W2050254589 @default.
• W2040332457 hasRelatedWork W2060890640 @default.
• W2040332457 hasRelatedWork W2078293551 @default.
• W2040332457 hasRelatedWork W2079578835 @default.

• next