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• W2040333119 startingPage "13" @default.
• W2040333119 abstract "A hallmark of Alzheimer's disease is production of amyloid β peptides resulting from aberrant cleavage of the amyloid precursor protein. Amyloid β assembles into fibrils under physiological conditions, through formation of neurotoxic intermediate oligomers. Tachykinin peptides are known to affect amyloid β neurotoxicity in cells. To understand the mechanism of this effect, we studied how tachykinins affect Aβ(1-40) aggregation in vitro. Fibrils grown in the presence of tachykinins exhibited reduced thioflavin T (ThT) fluorescence, while their morphology, observed in transmission electron microscopy (TEM), did not alter. Cross linking studies revealed that the distribution of low molecular weight species was not affected by tachykinins. Our results suggest that there may be a specific interaction between tachykinins and Aβ(1-40) that allows them to co-assemble. This effect may explain the reduction of Aβ(1-40) neurotoxicity in cells treated with tachykinins." @default.
• W2040333119 created "2016-06-24" @default.
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• W2040333119 date "2011-04-01" @default.
• W2040333119 modified "2023-10-16" @default.
• W2040333119 title "The effect of tachykinin neuropeptides on amyloid β aggregation" @default.
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• W2040333119 doi "https://doi.org/10.1016/j.bbrc.2011.02.067" @default.
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