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- W2040333844 abstract "Diagnosis of an anaplastic astrocytoma (World Health Organization grade III) is associated with a highly variable prognosis. The identification of clinical markers that allow a more careful delineation of this prognostic spectrum is urgently needed. In this study, we analysed 48 patients with a histological diagnosis of anaplastic astrocytoma and found peritumoral post-gadolinium contrast enhancement to be a clear prognostic marker of poor prognosis. Multivariate analysis also confirmed surgery type, Karnofsky Performance Status score (<70) and increasing age as independent adverse predictors of survival. The survival differences observed in the enhancing and non-enhancing lesions in patients diagnosed with anaplastic astrocytoma supports the existence of a broad anaplastic spectrum of disease, with enhancement being a clinical marker of tumour progression along this spectrum." @default.
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- W2040333844 date "2010-08-01" @default.
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- W2040333844 title "Post-contrast enhancement as a clinical indicator of prognosis in patients with anaplastic astrocytoma" @default.
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- W2040333844 doi "https://doi.org/10.1016/j.jocn.2009.12.015" @default.
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