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• W2040334516 abstract "Abstract Incorporation of Megatura crenulata hemocyanin into planar phospholipid bilayers results in the formation of ionic channels whose conductance can be directly measured. We have studied the effects of the pH on the electrical properties of these channels in the presence both of a K 2 SO 4 solution, at high and low concentration, and of a KCl one. We have found that the conductance of the channel depends on the proton concentration following a positive titration curve, i.e., increasing sigmoidally with the pH at all the concentrations used; at any given pH, it additionally increases sublinearly with the concentration of the salt. The sublinear conductance-concentration dependence can be reverted to an almost linear one by the addition of suitable amounts of an indifferent cation such a tetramethylammonium to keep the ionic strength constant. The current-voltage curve of the channel, which is strongly voltage-dependent, is shifted along the voltage axis towards negative values by an increase in the proton concentration. Calcium ions have similar effects. The selectivity of the channel for cations over anions is strongly pH-dependent in the case of a KCl solution, being lost at pH 4.5, but is almost invariant in a K 2 SO 4 solution. All experimental results are interpreted assuming the existence of a mechanism of voltage gating of the channel and of discrete negative charge fixed near its mouth. This charge can be neutralized by specific binding either of H + or of Ca 2+ ions. The dissociation constants from the channel found for these two ions are consistent with those given in the literature for the hemocyanin protein and indicate that carboxyl groups and/or histidines are involved in forming the negative charge of the pore." @default.
• W2040334516 created "2016-06-24" @default.
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• W2040334516 date "1986-04-01" @default.
• W2040334516 modified "2023-09-26" @default.
• W2040334516 title "Dependence of ion flow through the hemocyanin channel on a fixed charge at the pore mouth: effects of H + and Ca2+ ions" @default.
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• W2040334516 doi "https://doi.org/10.1016/0005-2736(86)90163-x" @default.
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