FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040336212> ?p ?o ?g. }

• W2040336212 endingPage "e170" @default.
• W2040336212 startingPage "e170" @default.
• W2040336212 abstract "The major cellular event in the development and progression of liver fibrosis is the activation of hepatic stellate cells (HSCs). Activated HSCs proliferate and produce excess collagen, leading to accumulation of scar matrix and fibrotic liver. As such, the induction of activated HSC death has been proposed as a means to achieve resolution of liver fibrosis. Here we demonstrate that cannabidiol (CBD), a major non-psychoactive component of the plant Cannabis sativa, induces apoptosis in activated HSCs through a cannabinoid receptor-independent mechanism. CBD elicits an endoplasmic reticulum (ER) stress response, characterized by changes in ER morphology and the initiation of RNA-dependent protein kinase-like ER kinase-, activating transcription factor-6-, and inositol-requiring ER-to-nucleus signal kinase-1 (IRE1)-mediated signaling cascades. Furthermore, CBD induces downstream activation of the pro-apoptotic IRE1/ASK1/c-Jun N-terminal kinase pathway, leading to HSC death. Importantly, we show that this mechanism of CBD-induced ER stress-mediated apoptosis is specific to activated HSCs, as it occurs in activated human and rat HSC lines, and in primary in vivo-activated mouse HSCs, but not in quiescent HSCs or primary hepatocytes from rat. Finally, we provide evidence that the elevated basal level of ER stress in activated HSCs has a role in their susceptibility to the pro-apoptotic effect of CBD. We propose that CBD, by selectively inducing death of activated HSCs, represents a potential therapeutic agent for the treatment of liver fibrosis." @default.
• W2040336212 created "2016-06-24" @default.
• W2040336212 creator A5004999764 @default.
• W2040336212 creator A5053630827 @default.
• W2040336212 creator A5088368115 @default.
• W2040336212 date "2011-06-09" @default.
• W2040336212 modified "2023-10-10" @default.
• W2040336212 title "Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis" @default.
• W2040336212 cites W1967973854 @default.
• W2040336212 cites W1974558745 @default.
• W2040336212 cites W1976161806 @default.
• W2040336212 cites W1986737010 @default.
• W2040336212 cites W1996081689 @default.
• W2040336212 cites W1997064567 @default.
• W2040336212 cites W1997189919 @default.
• W2040336212 cites W1998777017 @default.
• W2040336212 cites W1999924323 @default.
• W2040336212 cites W2002309357 @default.
• W2040336212 cites W2005025375 @default.
• W2040336212 cites W2012727463 @default.
• W2040336212 cites W2028612481 @default.
• W2040336212 cites W2032379590 @default.
• W2040336212 cites W2032743420 @default.
• W2040336212 cites W2038481055 @default.
• W2040336212 cites W2038774859 @default.
• W2040336212 cites W2041587548 @default.
• W2040336212 cites W2045280576 @default.
• W2040336212 cites W2065788111 @default.
• W2040336212 cites W2067927629 @default.
• W2040336212 cites W2080412278 @default.
• W2040336212 cites W2080901528 @default.
• W2040336212 cites W2081163089 @default.
• W2040336212 cites W2083438158 @default.
• W2040336212 cites W2099249565 @default.
• W2040336212 cites W2103826070 @default.
• W2040336212 cites W2111288662 @default.
• W2040336212 cites W2113480481 @default.
• W2040336212 cites W2115205812 @default.
• W2040336212 cites W2115282475 @default.
• W2040336212 cites W2119898593 @default.
• W2040336212 cites W2133644385 @default.
• W2040336212 cites W2134627852 @default.
• W2040336212 cites W2140401104 @default.
• W2040336212 cites W2143076346 @default.
• W2040336212 cites W2161803404 @default.
• W2040336212 cites W2165062244 @default.
• W2040336212 cites W4211260107 @default.
• W2040336212 doi "https://doi.org/10.1038/cddis.2011.52" @default.
• W2040336212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3168994" @default.
• W2040336212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21654828" @default.
• W2040336212 hasPublicationYear "2011" @default.
• W2040336212 type Work @default.
• W2040336212 sameAs 2040336212 @default.
• W2040336212 citedByCount "84" @default.
• W2040336212 countsByYear W20403362122012 @default.
• W2040336212 countsByYear W20403362122013 @default.
• W2040336212 countsByYear W20403362122014 @default.
• W2040336212 countsByYear W20403362122015 @default.
• W2040336212 countsByYear W20403362122016 @default.
• W2040336212 countsByYear W20403362122017 @default.
• W2040336212 countsByYear W20403362122018 @default.
• W2040336212 countsByYear W20403362122019 @default.
• W2040336212 countsByYear W20403362122020 @default.
• W2040336212 countsByYear W20403362122021 @default.
• W2040336212 countsByYear W20403362122022 @default.
• W2040336212 countsByYear W20403362122023 @default.
• W2040336212 crossrefType "journal-article" @default.
• W2040336212 hasAuthorship W2040336212A5004999764 @default.
• W2040336212 hasAuthorship W2040336212A5053630827 @default.
• W2040336212 hasAuthorship W2040336212A5088368115 @default.
• W2040336212 hasBestOaLocation W20403362121 @default.
• W2040336212 hasConcept C124160383 @default.
• W2040336212 hasConcept C134018914 @default.
• W2040336212 hasConcept C139447449 @default.
• W2040336212 hasConcept C158617107 @default.
• W2040336212 hasConcept C176891718 @default.
• W2040336212 hasConcept C184235292 @default.
• W2040336212 hasConcept C185592680 @default.
• W2040336212 hasConcept C190283241 @default.
• W2040336212 hasConcept C31573885 @default.
• W2040336212 hasConcept C502942594 @default.
• W2040336212 hasConcept C55493867 @default.
• W2040336212 hasConcept C62478195 @default.
• W2040336212 hasConcept C86803240 @default.
• W2040336212 hasConcept C90934575 @default.
• W2040336212 hasConcept C95444343 @default.
• W2040336212 hasConcept C97029542 @default.
• W2040336212 hasConceptScore W2040336212C124160383 @default.
• W2040336212 hasConceptScore W2040336212C134018914 @default.
• W2040336212 hasConceptScore W2040336212C139447449 @default.
• W2040336212 hasConceptScore W2040336212C158617107 @default.
• W2040336212 hasConceptScore W2040336212C176891718 @default.
• W2040336212 hasConceptScore W2040336212C184235292 @default.
• W2040336212 hasConceptScore W2040336212C185592680 @default.
• W2040336212 hasConceptScore W2040336212C190283241 @default.
• W2040336212 hasConceptScore W2040336212C31573885 @default.
• W2040336212 hasConceptScore W2040336212C502942594 @default.
• W2040336212 hasConceptScore W2040336212C55493867 @default.

• next