Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040337560> ?p ?o ?g. }
- W2040337560 endingPage "650" @default.
- W2040337560 startingPage "641" @default.
- W2040337560 abstract "L-type Ca(2+) channels (LTCCs) are major entry points for Ca(2+) in many cells. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is associated with cardiac LTCC complexes and increases channel open probability (P(O)) to dynamically increase Ca(2+) current (I(Ca)) and augment cellular Ca(2+) signaling by a process called facilitation. However, the critical molecular mechanisms for CaMKII localization to LTCCs and I(Ca) facilitation in cardiomyocytes have not been defined. We show CaMKII binds to the LTCC beta(2a) subunit and preferentially phosphorylates Thr498 in beta(2a). Mutation of Thr498 to Ala (T498A) in beta(2a) prevents CaMKII-mediated increases in the P(O) of recombinant LTCCs. Moreover, expression of beta(2a)(T498A) in adult cardiomyocytes ablates CaMKII-mediated I(Ca) facilitation, demonstrating that phosphorylation of beta(2a) at Thr498 modulates native calcium channels. These findings reveal a molecular mechanism for targeting CaMKII to LTCCs and facilitating I(Ca) that may modulate Ca(2+) entry in diverse cell types coexpressing CaMKII and the beta(2a) subunit." @default.
- W2040337560 created "2016-06-24" @default.
- W2040337560 creator A5008243514 @default.
- W2040337560 creator A5025425176 @default.
- W2040337560 creator A5035252118 @default.
- W2040337560 creator A5045487847 @default.
- W2040337560 creator A5046562663 @default.
- W2040337560 creator A5048118890 @default.
- W2040337560 creator A5048957333 @default.
- W2040337560 creator A5049920543 @default.
- W2040337560 date "2006-09-01" @default.
- W2040337560 modified "2023-10-03" @default.
- W2040337560 title "RETRACTED: L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the β Subunit by CaMKII" @default.
- W2040337560 cites W1561649131 @default.
- W2040337560 cites W1578255732 @default.
- W2040337560 cites W1601307541 @default.
- W2040337560 cites W1628979938 @default.
- W2040337560 cites W1940772596 @default.
- W2040337560 cites W1978354860 @default.
- W2040337560 cites W1991547841 @default.
- W2040337560 cites W1995550177 @default.
- W2040337560 cites W1996025078 @default.
- W2040337560 cites W1997958695 @default.
- W2040337560 cites W1998919517 @default.
- W2040337560 cites W1999764967 @default.
- W2040337560 cites W2001261561 @default.
- W2040337560 cites W2001594716 @default.
- W2040337560 cites W2007393704 @default.
- W2040337560 cites W2009765916 @default.
- W2040337560 cites W2026275430 @default.
- W2040337560 cites W2030598149 @default.
- W2040337560 cites W2034998738 @default.
- W2040337560 cites W2036937904 @default.
- W2040337560 cites W2052624503 @default.
- W2040337560 cites W2056459054 @default.
- W2040337560 cites W2057344543 @default.
- W2040337560 cites W2060517395 @default.
- W2040337560 cites W2061499765 @default.
- W2040337560 cites W2063972551 @default.
- W2040337560 cites W2068378623 @default.
- W2040337560 cites W2080213202 @default.
- W2040337560 cites W2080700455 @default.
- W2040337560 cites W2088236700 @default.
- W2040337560 cites W2090649248 @default.
- W2040337560 cites W2099753276 @default.
- W2040337560 cites W2103229713 @default.
- W2040337560 cites W2108383919 @default.
- W2040337560 cites W2112520390 @default.
- W2040337560 cites W2112798012 @default.
- W2040337560 cites W2116297568 @default.
- W2040337560 cites W2117975528 @default.
- W2040337560 cites W2122728009 @default.
- W2040337560 cites W2124374208 @default.
- W2040337560 cites W2127426595 @default.
- W2040337560 cites W2134798732 @default.
- W2040337560 cites W2135011583 @default.
- W2040337560 cites W2139060480 @default.
- W2040337560 cites W2140384407 @default.
- W2040337560 cites W2141479114 @default.
- W2040337560 cites W2149462562 @default.
- W2040337560 cites W2151912878 @default.
- W2040337560 cites W2152541148 @default.
- W2040337560 cites W2153456039 @default.
- W2040337560 cites W2154035354 @default.
- W2040337560 cites W2156263771 @default.
- W2040337560 cites W2159774610 @default.
- W2040337560 cites W2159998111 @default.
- W2040337560 cites W2165912575 @default.
- W2040337560 cites W2168556429 @default.
- W2040337560 cites W2169653175 @default.
- W2040337560 cites W2171971497 @default.
- W2040337560 doi "https://doi.org/10.1016/j.molcel.2006.07.006" @default.
- W2040337560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16949361" @default.
- W2040337560 hasPublicationYear "2006" @default.
- W2040337560 type Work @default.
- W2040337560 sameAs 2040337560 @default.
- W2040337560 citedByCount "182" @default.
- W2040337560 countsByYear W20403375602012 @default.
- W2040337560 countsByYear W20403375602013 @default.
- W2040337560 countsByYear W20403375602014 @default.
- W2040337560 countsByYear W20403375602015 @default.
- W2040337560 countsByYear W20403375602016 @default.
- W2040337560 countsByYear W20403375602017 @default.
- W2040337560 countsByYear W20403375602018 @default.
- W2040337560 countsByYear W20403375602019 @default.
- W2040337560 countsByYear W20403375602020 @default.
- W2040337560 countsByYear W20403375602021 @default.
- W2040337560 countsByYear W20403375602022 @default.
- W2040337560 countsByYear W20403375602023 @default.
- W2040337560 crossrefType "journal-article" @default.
- W2040337560 hasAuthorship W2040337560A5008243514 @default.
- W2040337560 hasAuthorship W2040337560A5025425176 @default.
- W2040337560 hasAuthorship W2040337560A5035252118 @default.
- W2040337560 hasAuthorship W2040337560A5045487847 @default.
- W2040337560 hasAuthorship W2040337560A5046562663 @default.
- W2040337560 hasAuthorship W2040337560A5048118890 @default.
- W2040337560 hasAuthorship W2040337560A5048957333 @default.
- W2040337560 hasAuthorship W2040337560A5049920543 @default.