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- W2040339721 abstract "Summary o (1) The results are given of a detailed study of 18 cases of pulmonary tuberculosis treated with isoniazid alone. (2) Sputum conversion occurred in 8 of the 18 patients by the 51st day. 5 later reverted to positive. In 2 of these the organisms isolated were sensitive to the drug, in the other 3 resistant. (3) In 10 of the 13 patients showing bacterial resistance, this first appeared between the 23rd and 62nd day. In all these cases the organisms were resistant to 50 μg./ml. isoniazid, the highest concentration tested. (4) Owing to the consistency of the degree of resistance attained no correlation was possible between this and the pretreatment state of the patient. Sputum conversion was less likely to occur in patients with gross cavitation. (5) The clinical significance of isoniazid resistance is confirmed by the increase in sputum positivity and the incidence of clinical and radiographic deterioration after the emergence of resistant organisms. (6) In 3 cases a reversion in the degree of resistance occurred after stopping the drug. The results of re-treatment with isoniazid suggested that such reversion is unlikely to be of any clinical importance." @default.
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- W2040339721 date "1954-07-01" @default.
- W2040339721 modified "2023-09-27" @default.
- W2040339721 title "Isoniazid resistance in patients with pulmonary tuberculosis treated on isoniazid alone" @default.
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- W2040339721 doi "https://doi.org/10.1016/s0041-3879(54)80131-0" @default.
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