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- W2040340033 abstract "Objective: Serum uric acid (SUA) is a relevant marker for cardiovascular disease in patients with hypertension and it has been implicated in target organ damage (TOD). However, the causative role has not been confirmed. Inflammation plays a pivotal role in TOD seen in essential hypertensive patients, while numerous studies confirm its interrelation with arterial stiffening. Thus, the purpose of the present study was to assess any possible links between SUA, inflammatory markers and arterial stiffness indices in never-treated essential hypertensive patients. Design and Methods: The study included 450 newly diagnosed patients, with stage I-II essential hypertension who referred to our outpatient clinic within a period of 24 months. All patients underwent full clinical and laboratory evaluation, while BP levels were assessed by 24-h ambulatory blood pressure monitoring (ABPM). Levels of hsCRP were measured using a validated high-sensitivity assay, while adiponectin was evaluated by a sandwich ELISA system. Finally, arterial stiffness assessment was made by carotid-femoral pulse wave velocity (PWVc-f), using the Complior devise. Results: On the basis of the median uric acid levels (5.3 mg/dl) the study population was divided into subjects with low (n = 149) and with high (n = 143) SUA values. In the entire study population, SUA was positively associated with 24-h BP (r = 0.297, p < 0.0001), hsCRP (r = 0.204, p = 0.001) and PWVc-f (r = 0.165, p = 0.009), while it was negatively related to adiponectin (r = -0.218, p < 0.0001). In multiple regression analysis SUA was independently associated with hsCRP [beta (SE) = 0.142(0.116), p = 0.02], adiponectine [beta(SE) = -0.154(0.005), p = 0.03] and 24-h BP [beta(SE) = 0.246(0.008), p = 0.001], while PWVc-f failed to present such an association(p = NS). Conclusions: There is a strong independent interrelation between SUA, CRP, 24h-BP and adiponectin levels in essential hypertensive patients, while no such association was confirmed for arterial stiffness. Further studies should be conducted so as to clarify the possible causative background of these interrelations." @default.
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- W2040340033 date "2010-06-01" @default.
- W2040340033 modified "2023-09-27" @default.
- W2040340033 title "URIC ACID INTERRELATIONS WITH ADIPONECTIN, LOW-GRADE INFLAMMATION AND ARTERIAL STIFFNESS IN ESSENTIAL NEVER-TREATED HYPERTENSIVE PATIENTS: 8B.02" @default.
- W2040340033 doi "https://doi.org/10.1097/01.hjh.0000379484.53198.cd" @default.
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