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- W2040346013 abstract "The effects of 3 different non-noxious stressors on body temperature (Tb) were investigated in the rat: (1) loose restraint in cyclinders, (2) removal of the rats from cylinders, exposure to a novel environment and replacement cylinders, a stressor called here ’novelty‘, and (3) gentle holding of the rats by the nape the neck. Loose restraint and ‘novelty’ produced hyperthemia. On the contrary, holing induced hypothermia. Hypophysectomy (HX) reduced basal Tb, abolished restraint hyperthemia and reduced both ‘novelty’ hyperthemia. Dexamethasone (DEXA) had no effect upon either restraint of novelty hyperthemia but reduced the hyperthemia. Naloxone (Nx) produced a slight fall in basal Tb accounting for its reduction and ‘novelty’ hyperthemias: it did not affect holding hypothemia. The inhibitory effects of HX suggest a participation if the pituitary in the hyperthemias; the neurointermediate lobe would be involved as the hyperthemiad were not affected by DEXA, which is known to block the stress-induced release of pituitary secretions from the anterior lobe but not from the neurointermediate lobe. In contrast, substances from the anterior lobe might participate in hypothermia due to holding since it is reduced by HX and DEXA. As to the effects of Nx, endogenous opioids would not be significantly involved in the effects of the stressors used in this study; they might play, if any only a minor role in the regulation of basal Tb. These results are compared with those previously obtained on nociception using the same non-noxious stressors. It emerges that, depending in the stressor, different types of association between thermoregulation may occur, i.e. hyperthemia with analgesia, hyperthermia with hyperalgesia and hypothermia with hyperalgesia." @default.
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- W2040346013 date "1984-04-01" @default.
- W2040346013 modified "2023-10-18" @default.
- W2040346013 title "Regulation of body temperature and nocipception induced by non-noxious stress in rat" @default.
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- W2040346013 doi "https://doi.org/10.1016/0006-8993(84)90537-7" @default.
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