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- W2040346023 abstract "We report two double-blind, placebo-controlled studies of the effects of disodium etidronate (EHDP) on the incidence and severity of heterotopic ossification following total hip arthroplasty or spinal cord injury. The large placebo groups in these studies allowed the estimation of the incidence of heterotopic ossification in these patient populations. Heterotopic ossification occurred in 65% of patients after hip replacement and in the majority of these within 15 weeks. Clinically significant ossification occurred in 19% of affected patients. The incidence of heterotopic calcification after spinal cord Injury was less (35%) but followed a similar natural history. Treatment with EHDP reduced the incidence and severity of lesions both at the time of stopping EHDP and up to 9 months after treatment. Les auteurs rapportent deux études réalisées an double insu avec contrôle par un placebo dans le but d'analyser les effets de l'étidronate disodique (EHDP) sur la fréquence de survenue et la sévé rité des ossifications hétérotopiques après prothèse totale de hanche ou traumatisme médullaire. L'effectif important des groupes recevant un placebo a permis l'évaluation de la fréquence des ossifications hétérotopiques dans lee populations observées. Ces ossifications surviennent chez 65 pour cent des sujets ayant subi une prothèse de hanche, dans la majorité des cas dans les 15 premières semaines après l'intervention. Ces ossifications ont une traduction clinique chez 19 pour cent des malades. La fréquence de survenue est moindre (35%), mais suit une évolution spontanée identique. Dans les deux groupes, le traitement par l'EHDP réduit la fréquence et la gravité des lésions à la fois on fin de cure, et ceci jusqu'à 9 mois après l'arrêt de l'EHDP." @default.
- W2040346023 created "2016-06-24" @default.
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- W2040346023 date "1981-01-01" @default.
- W2040346023 modified "2023-09-25" @default.
- W2040346023 title "Heteretepic ossification following hip replacement or spinal cord injury. Two clinical studies with EHDP" @default.
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- W2040346023 doi "https://doi.org/10.1016/0221-8747(81)90050-3" @default.
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