Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040346915> ?p ?o ?g. }
- W2040346915 endingPage "513" @default.
- W2040346915 startingPage "493" @default.
- W2040346915 abstract "Abstract Minimized potential energy calculations have been employed to locate and evaluate energetically a number of different models for DNA modified at carbon-8 of guanine by acetylaminofluorene (AAF). Three different duplex nonamer sequences were investigated. In addition to syn guanine models which have some denaturation and a Z-DNA model, we have found two new types of structures in which guanine remains syn and the AAF is placed in the minor groove of a B-DNA helix. One type features Hoogsteen base pairing between the modified guanine and protonated cytosine, with a sharply bent helix. The other (here termed the “wedge” model because the aromatic amine is wedged into the minor groove) maintains a single hydrogen bond between O6 of the modified guanine and N3 of protonated cytosine, with much less deformation of the helix, and close Van der Waals contacts between the AAF and the walls of the minor groove. Both types of structures (as well as the related forms produced by deprotonation of cytosine) are energetically important in all three sequences examined. The wedge-type model, which is most favored except in alternating G-C sequences, has been previously observed in a combined NMR and computational characterization of an aminofluorene (AF) modified guanine opposite adenine in a DNA duplex undecamer (D. Norman, P. Abuaf, B.E. Hingerty, D. Live, D. Grunberger, S. Broyde and D.J. Patel, Biochemistry 28, 7462 (1989))." @default.
- W2040346915 created "2016-06-24" @default.
- W2040346915 creator A5016469712 @default.
- W2040346915 creator A5045073997 @default.
- W2040346915 creator A5079258814 @default.
- W2040346915 date "1989-12-01" @default.
- W2040346915 modified "2023-09-24" @default.
- W2040346915 title "Minor-Groove Binding Models for Acetylaminofluorene Modified DNA" @default.
- W2040346915 cites W1971417566 @default.
- W2040346915 cites W1973218155 @default.
- W2040346915 cites W1973632665 @default.
- W2040346915 cites W1976957812 @default.
- W2040346915 cites W1979140966 @default.
- W2040346915 cites W1981229526 @default.
- W2040346915 cites W1982856746 @default.
- W2040346915 cites W1983371414 @default.
- W2040346915 cites W1984181406 @default.
- W2040346915 cites W1986236180 @default.
- W2040346915 cites W1989447644 @default.
- W2040346915 cites W1989622567 @default.
- W2040346915 cites W2008108727 @default.
- W2040346915 cites W2009378502 @default.
- W2040346915 cites W2011621564 @default.
- W2040346915 cites W2015020278 @default.
- W2040346915 cites W2015141145 @default.
- W2040346915 cites W2016511045 @default.
- W2040346915 cites W2017633714 @default.
- W2040346915 cites W2018860604 @default.
- W2040346915 cites W2019809667 @default.
- W2040346915 cites W2021436957 @default.
- W2040346915 cites W2022745699 @default.
- W2040346915 cites W2025465319 @default.
- W2040346915 cites W2028255123 @default.
- W2040346915 cites W2030223140 @default.
- W2040346915 cites W2036173104 @default.
- W2040346915 cites W2039300316 @default.
- W2040346915 cites W2039493473 @default.
- W2040346915 cites W2039641512 @default.
- W2040346915 cites W2042812247 @default.
- W2040346915 cites W2043995349 @default.
- W2040346915 cites W2049334124 @default.
- W2040346915 cites W2051119393 @default.
- W2040346915 cites W2054126064 @default.
- W2040346915 cites W2061098084 @default.
- W2040346915 cites W2061822610 @default.
- W2040346915 cites W2066417597 @default.
- W2040346915 cites W2089351342 @default.
- W2040346915 cites W2092716257 @default.
- W2040346915 cites W2093521719 @default.
- W2040346915 cites W2093674441 @default.
- W2040346915 cites W2094767801 @default.
- W2040346915 cites W2096829553 @default.
- W2040346915 cites W2151490451 @default.
- W2040346915 cites W2162556014 @default.
- W2040346915 cites W2172225183 @default.
- W2040346915 cites W2180006187 @default.
- W2040346915 cites W2219609297 @default.
- W2040346915 cites W26416210 @default.
- W2040346915 cites W4232854069 @default.
- W2040346915 cites W4236123066 @default.
- W2040346915 doi "https://doi.org/10.1080/07391102.1989.10508506" @default.
- W2040346915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2627297" @default.
- W2040346915 hasPublicationYear "1989" @default.
- W2040346915 type Work @default.
- W2040346915 sameAs 2040346915 @default.
- W2040346915 citedByCount "37" @default.
- W2040346915 countsByYear W20403469152012 @default.
- W2040346915 countsByYear W20403469152013 @default.
- W2040346915 countsByYear W20403469152014 @default.
- W2040346915 countsByYear W20403469152015 @default.
- W2040346915 countsByYear W20403469152017 @default.
- W2040346915 countsByYear W20403469152020 @default.
- W2040346915 crossrefType "journal-article" @default.
- W2040346915 hasAuthorship W2040346915A5016469712 @default.
- W2040346915 hasAuthorship W2040346915A5045073997 @default.
- W2040346915 hasAuthorship W2040346915A5079258814 @default.
- W2040346915 hasConcept C104317684 @default.
- W2040346915 hasConcept C112887158 @default.
- W2040346915 hasConcept C118629725 @default.
- W2040346915 hasConcept C145148216 @default.
- W2040346915 hasConcept C178790620 @default.
- W2040346915 hasConcept C185581394 @default.
- W2040346915 hasConcept C185592680 @default.
- W2040346915 hasConcept C18903297 @default.
- W2040346915 hasConcept C2776023528 @default.
- W2040346915 hasConcept C2778301229 @default.
- W2040346915 hasConcept C2778530040 @default.
- W2040346915 hasConcept C2779965526 @default.
- W2040346915 hasConcept C32909587 @default.
- W2040346915 hasConcept C512185932 @default.
- W2040346915 hasConcept C552990157 @default.
- W2040346915 hasConcept C55493867 @default.
- W2040346915 hasConcept C61234307 @default.
- W2040346915 hasConcept C71240020 @default.
- W2040346915 hasConcept C8010536 @default.
- W2040346915 hasConcept C86803240 @default.
- W2040346915 hasConcept C99611785 @default.
- W2040346915 hasConceptScore W2040346915C104317684 @default.