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- W2040348749 startingPage "21" @default.
- W2040348749 abstract "Advances in the understanding of the aetiology, epidemiology, pathogenesis and microbiology of periodontal pocket flora have revolutionized the strategies for the management of intraperiodontal pocket diseases. Intra-pocket, sustained release, drug delivery devices have been shown to be clinically effective in the treatment of periodontal infections. Several degradable and non-degradable devices are under investigation for the delivery of antimicrobial agents into the periodontal pocket including non-biodegradable fibres, films (biodegradable and non-biodegradable), bio-absorbable dental materials, biodegradable gels/ointments, injectables and microcapsules. With the realization that pocket bacteria accumulate as biofilms, studies are now being directed towards eliminating/killing biofilm concentrations rather than their planktonic (fluid phase) counterparts. Intraperiodontal pocket drug delivery has emerged as a novel paradigm for the future research. Similarly, bioadhesive delivery systems are explored that could significantly improve oral therapeutics for periodontal disease and mucosal lesions. A strategy is to target a wide range of molecular mediators of tissue destruction and hence arrest periodontal disease progression. Research into regenerating periodontal structures lost as a result of disease has also shown substantial progress in the last 25 years." @default.
- W2040348749 created "2016-06-24" @default.
- W2040348749 creator A5030635639 @default.
- W2040348749 creator A5055309976 @default.
- W2040348749 creator A5074428922 @default.
- W2040348749 date "2000-01-01" @default.
- W2040348749 modified "2023-10-17" @default.
- W2040348749 title "Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases" @default.
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