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• W2040356267 abstract "Cytochrome c expression and mitochondrial biogenesis can be invoked by elevated intracellular Ca 2+ in muscle cells. To characterize the potential role of Ca 2+ as a messenger involved in mitochondrial biogenesis in muscle, we determined the effects of the Ca 2+ ionophore A-23187 on the expression of nuclear- and mitochondrially encoded genes. Treatment of myotubes with 1 μM A-23187 for 48–96 h increased nuclear-encoded β-subunit F 1 ATPase and malate dehydrogenase (MDH) mRNA levels by 50–100% ( P < 0.05) but decreased mRNA levels of glutamate dehydrogenase (GDH) by 19% ( P < 0.05). mRNA levels of the cytochrome c oxidase (COX) nuclear-encoded subunits IV, Vb, and VIc were unchanged, whereas the mitochondrially encoded subunits COX II and COX III were decreased by 30 and 70%, respectively ( P < 0.05). This was paralleled by a 20% decrease ( P < 0.05) in COX activity. These data suggest that cytoplasmic Ca 2+ differentially regulates the mRNA level of nuclear and mitochondrial genes. The decline in COX II and III mRNA may be mediated by Tfam, because A-23187 modestly reduced Tfam levels by 48 h. A-23187 induced time-dependent increases in Egr-1 mRNA, along with the activation of ERK1/2 and AMP-activated protein kinase. MEK inhibition with PD-98059 attenuated the increase in Egr-1 mRNA. A-23187 also increased Egr-1, serum response factor, and Sp1 protein expression, transcription factors implicated in mitochondrial biogenesis. Egr-1 overexpression increased nuclear-encoded cytochrome c transcriptional activation by 1.5-fold ( P < 0.05) and reduced GDH mRNA by 37% ( P < 0.05) but had no effect on MDH or β-subunit F 1 ATPase mRNA. These results indicate that changes in intracellular Ca 2+ can modify mitochondrial phenotype, in part via the involvement of Egr-1." @default.
• W2040356267 created "2016-06-24" @default.
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• W2040356267 date "2004-05-01" @default.
• W2040356267 modified "2023-10-15" @default.
• W2040356267 title "Calcium-regulated changes in mitochondrial phenotype in skeletal muscle cells" @default.
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• W2040356267 doi "https://doi.org/10.1152/ajpcell.00418.2003" @default.
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