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- W2040365728 abstract "We started concurrent chemoradiation therapy (CCRT) for stage II-IV nasopharyngeal carcinoma since 1999. From April 2000 to November 2005 we used 2 courses of cisplatin plus fluorouracil during radiation therapy. From December 2005 to October 2011, we changed the regimen to total 5 courses of weekly cisplatin administration without fluorouracil. The aim of this study is retrospective comparison of these two chemotherapy regimen for overall survival, progression free survival, local control and acute toxicity. Patients who followed more than six months after treatment completion were included in this analysis. For CCRT with cisplatin plus fluorouracil, cisplatin (80 mg/m2) plus fluorouracil (400 mg per m2 per day for days 2-5) every 3 weeks for two cycles were administrated during radiation therapy and for CCRT with weekly cisplatin, patient received cisplatin 40 mg/m2 weekly for five cycles during radiation therapy. As for the radiation therapy, patients were treated with three dimensional conformal radiation therapy until 2004. After that, intensity modulated radiation therapy (IMRT) was used in principle. A total of 50 patients with nasopharyngeal carcinoma were treated with CCRT in this period. Twenty five (stage II: 4, III: 16, IV: 5) patients were treated by CCRT with cisplatin plus fluorouracil and also 25 (stage II: 10, III: 10, IV: 5) patients were treated with weekly cisplatin. Median follow up period was 71 months (range 7-118) for cisplatin plus fluorouracil and 34 months (range 8-62) for weekly cisplatin. Five patients received adjuvant chemotherapy consist of cisplatin and fluorouracil after CCRT with weekly cisplatin and five patients received induction chemotherapy (four: cisplatin, fluorouracil and docetaxel and one: oral S-1) prior to CCRT. Cox-regression multivariate analysis showed that sex, stage II or more, IMRT or not, and fluorouracil or not, were not prognostic factors on overall survival (p=0.85, 0.17, 0.24, 0.36, respectively). Three years overall survival rate, progression free survival rate and local control (primary site) rate were 84%, 58%, 82% for cisplatin plus fluorouracil and 90%, 49%, 72% for weekly cisplatin respectively (p=0.82, 0.47, 0.52, respectively). Seven patients (24%) experienced grade 4 dermatitis with cisplatin plus fluorouracil and no patients with weekly cisplatin (p=0.0025). Grade 3-4 leukopenia was significantly more frequent with weekly cisplatin (p=0.0001). Although toxicity profile was different, these two concurrent chemoradiation therapy regimens result in similar survival and local control." @default.
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- W2040365728 date "2012-11-01" @default.
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- W2040365728 title "Retrospective Comparison Between Cisplatin Plus Fluorouracil and Weekly Cisplatin in Concurrent Chemoradiation Therapy Setting for Stage II-IV Nasopharyngeal Carcinoma" @default.
- W2040365728 doi "https://doi.org/10.1016/j.ijrobp.2012.07.1286" @default.
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