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• W2040365962 startingPage "107" @default.
• W2040365962 abstract "Pigment cells of the zebrafish, Danio rerio, offer an exceptionally tractable system for studying the genetic and cellular bases of cell fate decisions. In the zebrafish, neural crest cells generate three types of pigment cells during embryogenesis: yellow xanthophores, iridescent iridophores and black melanophores. In this study, we present evidence for a model whereby melanophores and iridophores descend from a common precursor whose fate is regulated by an interplay between the transcription factors Mitf and Foxd3. Loss of mitfa, a key regulator of melanophore development, resulted in supernumerary ectopic iridophores while loss of foxd3, a mitfa repressor, resulted in fewer iridophores. Double mutants showed a restoration of iridophores, suggesting that one of Foxd3's roles is to suppress mitfa to promote iridophore development. Foxd3 co-localized with pnp4a, a novel marker of early iridophore development, and was necessary for its expression. A considerable overlap was found between iridoblast and melanoblast markers but not xanthoblast markers, which resolved as cells began to differentiate. Cell lineage analyses using the photoconvertible marker, EosFP, revealed that both melanophores and iridophores develop from a mitfa+ precursor. Taken together, our data reveal a Foxd3/mitfa transcriptional switch that governs whether a bi-potent pigment precursor will attain either an iridophore or a melanophore fate." @default.
• W2040365962 created "2016-06-24" @default.
• W2040365962 creator A5016120668 @default.
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• W2040365962 creator A5055001531 @default.
• W2040365962 creator A5075131282 @default.
• W2040365962 date "2010-08-01" @default.
• W2040365962 modified "2023-10-16" @default.
• W2040365962 title "Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest" @default.
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• W2040365962 cites W1944929000 @default.
• W2040365962 cites W1963652662 @default.
• W2040365962 cites W1968263299 @default.
• W2040365962 cites W1970292137 @default.
• W2040365962 cites W1972070840 @default.
• W2040365962 cites W1973130577 @default.
• W2040365962 cites W1974723367 @default.
• W2040365962 cites W1984342331 @default.
• W2040365962 cites W1986238441 @default.
• W2040365962 cites W1986506040 @default.
• W2040365962 cites W1995138630 @default.
• W2040365962 cites W1996664737 @default.
• W2040365962 cites W1997830187 @default.
• W2040365962 cites W1997889534 @default.
• W2040365962 cites W1998756807 @default.
• W2040365962 cites W2000146676 @default.
• W2040365962 cites W2006732267 @default.
• W2040365962 cites W2007834880 @default.
• W2040365962 cites W2008118174 @default.
• W2040365962 cites W2010684135 @default.
• W2040365962 cites W2013204606 @default.
• W2040365962 cites W2013538305 @default.
• W2040365962 cites W2015086441 @default.
• W2040365962 cites W2020788680 @default.
• W2040365962 cites W2025903846 @default.
• W2040365962 cites W2026321840 @default.
• W2040365962 cites W2028994367 @default.
• W2040365962 cites W2036159004 @default.
• W2040365962 cites W2037909661 @default.
• W2040365962 cites W2054191209 @default.
• W2040365962 cites W2054364851 @default.
• W2040365962 cites W2055238787 @default.
• W2040365962 cites W2063671952 @default.
• W2040365962 cites W2066231916 @default.
• W2040365962 cites W2067285199 @default.
• W2040365962 cites W2070314600 @default.
• W2040365962 cites W2071647127 @default.
• W2040365962 cites W2074091569 @default.
• W2040365962 cites W2078002199 @default.
• W2040365962 cites W2080930253 @default.
• W2040365962 cites W2081462173 @default.
• W2040365962 cites W2086784184 @default.
• W2040365962 cites W2088937096 @default.
• W2040365962 cites W2089941045 @default.
• W2040365962 cites W2092133045 @default.
• W2040365962 cites W2095111365 @default.
• W2040365962 cites W2106771547 @default.
• W2040365962 cites W2107006976 @default.
• W2040365962 cites W2116387002 @default.
• W2040365962 cites W2122545078 @default.
• W2040365962 cites W2123300858 @default.
• W2040365962 cites W2125349610 @default.
• W2040365962 cites W2128557089 @default.
• W2040365962 cites W2129428247 @default.
• W2040365962 cites W2130743529 @default.
• W2040365962 cites W2130987003 @default.
• W2040365962 cites W2140238053 @default.
• W2040365962 cites W2145297890 @default.
• W2040365962 cites W2150242706 @default.
• W2040365962 cites W2153649171 @default.
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• W2040365962 cites W2159969192 @default.
• W2040365962 cites W2161055228 @default.
• W2040365962 cites W2161533644 @default.
• W2040365962 cites W2162497387 @default.
• W2040365962 cites W2164927488 @default.
• W2040365962 cites W2165389148 @default.
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• W2040365962 doi "https://doi.org/10.1016/j.ydbio.2010.04.023" @default.
• W2040365962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2909359" @default.
• W2040365962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20460180" @default.
• W2040365962 hasPublicationYear "2010" @default.
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