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- W2040367983 endingPage "570" @default.
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- W2040367983 abstract "The deposition of beta-amyloid (Abeta) in the brain is a neuropathological feature of Alzheimer's disease. Abeta is cleaved from its precursor protein (APP) by processing at its N and C termini by enzymes known as beta- and gamma-secretases,respectively. The identity of these enzymes has been elusive but the search for the N-terminal secretase might have ended recently with the almost simultaneous publication by five major laboratories claiming a transmembrane aspartic proteinase to be the long sought after beta-secretase. Even at this early stage of its characterization, this aspartic proteinase fulfils many of the key criteria necessary for beta-secretase. The race is now on to develop inhibitors that could prove effective in halting the progression of Alzheimer's disease." @default.
- W2040367983 created "2016-06-24" @default.
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- W2040367983 date "2000-11-01" @default.
- W2040367983 modified "2023-10-18" @default.
- W2040367983 title "In search of an enzyme: the β-secretase of Alzheimer's disease is an aspartic proteinase" @default.
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- W2040367983 doi "https://doi.org/10.1016/s0166-2236(00)01647-7" @default.
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