Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040372357> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2040372357 endingPage "309" @default.
- W2040372357 startingPage "301" @default.
- W2040372357 abstract "Influence of JTH-601 [N-(3-hydroxy-6-methoxy-2,4,5-trimethylbenzyl)-N-methyl-2-(4-hydroxy-2-isopropyl-5-methylphenoxy)ethylamine hemifumarate], a selective alpha1-adrenoceptor antagonist, on alpha1-mediated positive inotropic effect (PIE) was studied in isolated rabbit papillary muscle (1 Hz at 37 degrees C). JTH-601 (0.1-10 microM) shifted the concentration-response curve (CRC) for PIE of phenylephrine mediated by alpha1-adrenoceptor (with timolol at 1 microM) to the right and downward. In the presence of 100 nM WB 4101, an alpha1A antagonist, the shift to the right disappeared and JTH-601 (1-3 microM) shifted CRC for phenylephrine downward. The antagonistic action of JTH-601 was unchanged by 100 nM (+)-niguldipine, another alpha1A antagonist. Following pretreatment with 10 microM chloroethylclonidine, an alpha1B antagonist, the shift of CRC for phenylephrine to the right disappeared and JTH-601 (3-10 microM) shifted CRC downward. Antagonistic action of JTH-601 (3 microM) was unaltered by 100 nM BMY 7378, an alpha1D antagonist. JTH-601 (10 microM) had no effect on beta-mediated PIE of isoproterenol. These results indicate that JTH-601 exerts an inhibitory action on alpha1-mediated PIE through antagonism of alpha1A- and/or alpha1B-adrenoceptors in rabbit ventricular myocardium. As an alpha1 antagonist, JTH-601 is much less potent in rabbit ventricular muscle than in smooth muscle." @default.
- W2040372357 created "2016-06-24" @default.
- W2040372357 creator A5013489946 @default.
- W2040372357 creator A5021629429 @default.
- W2040372357 creator A5055983828 @default.
- W2040372357 date "2000-01-01" @default.
- W2040372357 modified "2023-09-26" @default.
- W2040372357 title "Pharmacological Characteristics of Inhibitory Action of the Selective α1-Antagonist JTH-601 on the Positive Inotropic Effect Mediated by α1-drenoceptors in Isolated Rabbit Papillary Muscle" @default.
- W2040372357 cites W1964993772 @default.
- W2040372357 cites W1978012392 @default.
- W2040372357 cites W1990033171 @default.
- W2040372357 cites W2000360015 @default.
- W2040372357 cites W2010346714 @default.
- W2040372357 cites W2010407255 @default.
- W2040372357 cites W2014747325 @default.
- W2040372357 cites W2017436626 @default.
- W2040372357 cites W2037697488 @default.
- W2040372357 cites W2047974282 @default.
- W2040372357 cites W2048373362 @default.
- W2040372357 cites W8861334 @default.
- W2040372357 doi "https://doi.org/10.1254/jjp.84.301" @default.
- W2040372357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11138731" @default.
- W2040372357 hasPublicationYear "2000" @default.
- W2040372357 type Work @default.
- W2040372357 sameAs 2040372357 @default.
- W2040372357 citedByCount "1" @default.
- W2040372357 crossrefType "journal-article" @default.
- W2040372357 hasAuthorship W2040372357A5013489946 @default.
- W2040372357 hasAuthorship W2040372357A5021629429 @default.
- W2040372357 hasAuthorship W2040372357A5055983828 @default.
- W2040372357 hasBestOaLocation W20403723571 @default.
- W2040372357 hasConcept C126322002 @default.
- W2040372357 hasConcept C134018914 @default.
- W2040372357 hasConcept C141071460 @default.
- W2040372357 hasConcept C155710745 @default.
- W2040372357 hasConcept C170493617 @default.
- W2040372357 hasConcept C17077164 @default.
- W2040372357 hasConcept C185592680 @default.
- W2040372357 hasConcept C2776885963 @default.
- W2040372357 hasConcept C2777274916 @default.
- W2040372357 hasConcept C2777952589 @default.
- W2040372357 hasConcept C2778073030 @default.
- W2040372357 hasConcept C2781092963 @default.
- W2040372357 hasConcept C71924100 @default.
- W2040372357 hasConcept C84393581 @default.
- W2040372357 hasConceptScore W2040372357C126322002 @default.
- W2040372357 hasConceptScore W2040372357C134018914 @default.
- W2040372357 hasConceptScore W2040372357C141071460 @default.
- W2040372357 hasConceptScore W2040372357C155710745 @default.
- W2040372357 hasConceptScore W2040372357C170493617 @default.
- W2040372357 hasConceptScore W2040372357C17077164 @default.
- W2040372357 hasConceptScore W2040372357C185592680 @default.
- W2040372357 hasConceptScore W2040372357C2776885963 @default.
- W2040372357 hasConceptScore W2040372357C2777274916 @default.
- W2040372357 hasConceptScore W2040372357C2777952589 @default.
- W2040372357 hasConceptScore W2040372357C2778073030 @default.
- W2040372357 hasConceptScore W2040372357C2781092963 @default.
- W2040372357 hasConceptScore W2040372357C71924100 @default.
- W2040372357 hasConceptScore W2040372357C84393581 @default.
- W2040372357 hasIssue "3" @default.
- W2040372357 hasLocation W20403723571 @default.
- W2040372357 hasLocation W20403723572 @default.
- W2040372357 hasOpenAccess W2040372357 @default.
- W2040372357 hasPrimaryLocation W20403723571 @default.
- W2040372357 hasRelatedWork W1966357256 @default.
- W2040372357 hasRelatedWork W1970208811 @default.
- W2040372357 hasRelatedWork W1988153710 @default.
- W2040372357 hasRelatedWork W1994320988 @default.
- W2040372357 hasRelatedWork W2029100518 @default.
- W2040372357 hasRelatedWork W2033761402 @default.
- W2040372357 hasRelatedWork W2040372357 @default.
- W2040372357 hasRelatedWork W2065667368 @default.
- W2040372357 hasRelatedWork W2129759033 @default.
- W2040372357 hasRelatedWork W3146381569 @default.
- W2040372357 hasVolume "84" @default.
- W2040372357 isParatext "false" @default.
- W2040372357 isRetracted "false" @default.
- W2040372357 magId "2040372357" @default.
- W2040372357 workType "article" @default.