Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040373312> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2040373312 endingPage "5603" @default.
- W2040373312 startingPage "5600" @default.
- W2040373312 abstract "Antioxidants may play an important role in preventing free radical damage associated with aging by interfering directly in the generation of radicals or by scavenging them. We investigated the effects of a high vitamin E and/or a high beta-carotene diet on aging of the anion transporter, band 3, in lymphocytes and brain. The band 3 proteins function as anion transporters, acid base regulators, C02 transporters, and structural proteins that provide a framework for membrane lipids and that link the plasma membrane to the cytoskeleton. Senescent cell antigen (SCA), which terminates the life of cells, is a degradation product of band 3. This study was conducted as a double-blind study in which eight groups of middle-aged or old mice received either high levels of beta-carotene and/or vitamin E or standard levels of these supplements in their diets. Anion transport kinetic assays were performed on isolated splenic lymphocytes. Immunoreactivity of an antibody that recognizes aging changes in old band 3 preceding generation of SCA was used to quantitate aged band 3 in brain tissue. Results indicate that vitamin E prevented the observed age-related decline in anion transport by lymphocytes and the generation of aged band 3 leading to SCA formation. beta-Carotene had no significant effect on the results of either assay. Since increased aged band 3 and decreased anion transport are initial steps in band 3 aging, which culminates in the generation of SCA and cellular removal, vitamin E prevents or delays aging of band 3-related proteins in lymphocytes and brain." @default.
- W2040373312 created "2016-06-24" @default.
- W2040373312 creator A5005810813 @default.
- W2040373312 creator A5008685644 @default.
- W2040373312 creator A5084242595 @default.
- W2040373312 creator A5090087211 @default.
- W2040373312 date "1996-05-28" @default.
- W2040373312 modified "2023-10-11" @default.
- W2040373312 title "Vitamin E prevents oxidative modification of brain and lymphocyte band 3 proteins during aging." @default.
- W2040373312 cites W149273096 @default.
- W2040373312 cites W1978096154 @default.
- W2040373312 cites W1983202426 @default.
- W2040373312 cites W1999698251 @default.
- W2040373312 cites W2041341672 @default.
- W2040373312 cites W2056620406 @default.
- W2040373312 cites W2064391986 @default.
- W2040373312 cites W2105843079 @default.
- W2040373312 cites W2116933718 @default.
- W2040373312 cites W2119740011 @default.
- W2040373312 cites W2125254733 @default.
- W2040373312 cites W2127713503 @default.
- W2040373312 cites W2140802223 @default.
- W2040373312 cites W2142697870 @default.
- W2040373312 cites W2160657516 @default.
- W2040373312 cites W2160822846 @default.
- W2040373312 cites W2311290643 @default.
- W2040373312 cites W2409653892 @default.
- W2040373312 cites W2414611839 @default.
- W2040373312 cites W2418065532 @default.
- W2040373312 cites W59698840 @default.
- W2040373312 doi "https://doi.org/10.1073/pnas.93.11.5600" @default.
- W2040373312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39293" @default.
- W2040373312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8643622" @default.
- W2040373312 hasPublicationYear "1996" @default.
- W2040373312 type Work @default.
- W2040373312 sameAs 2040373312 @default.
- W2040373312 citedByCount "24" @default.
- W2040373312 countsByYear W20403733122016 @default.
- W2040373312 countsByYear W20403733122021 @default.
- W2040373312 countsByYear W20403733122022 @default.
- W2040373312 crossrefType "journal-article" @default.
- W2040373312 hasAuthorship W2040373312A5005810813 @default.
- W2040373312 hasAuthorship W2040373312A5008685644 @default.
- W2040373312 hasAuthorship W2040373312A5084242595 @default.
- W2040373312 hasAuthorship W2040373312A5090087211 @default.
- W2040373312 hasBestOaLocation W20403733121 @default.
- W2040373312 hasConcept C104317684 @default.
- W2040373312 hasConcept C126322002 @default.
- W2040373312 hasConcept C144647389 @default.
- W2040373312 hasConcept C149011108 @default.
- W2040373312 hasConcept C185592680 @default.
- W2040373312 hasConcept C203014093 @default.
- W2040373312 hasConcept C2776589458 @default.
- W2040373312 hasConcept C2777551382 @default.
- W2040373312 hasConcept C2777761686 @default.
- W2040373312 hasConcept C2778004101 @default.
- W2040373312 hasConcept C41625074 @default.
- W2040373312 hasConcept C55493867 @default.
- W2040373312 hasConcept C57600042 @default.
- W2040373312 hasConcept C71924100 @default.
- W2040373312 hasConcept C86803240 @default.
- W2040373312 hasConceptScore W2040373312C104317684 @default.
- W2040373312 hasConceptScore W2040373312C126322002 @default.
- W2040373312 hasConceptScore W2040373312C144647389 @default.
- W2040373312 hasConceptScore W2040373312C149011108 @default.
- W2040373312 hasConceptScore W2040373312C185592680 @default.
- W2040373312 hasConceptScore W2040373312C203014093 @default.
- W2040373312 hasConceptScore W2040373312C2776589458 @default.
- W2040373312 hasConceptScore W2040373312C2777551382 @default.
- W2040373312 hasConceptScore W2040373312C2777761686 @default.
- W2040373312 hasConceptScore W2040373312C2778004101 @default.
- W2040373312 hasConceptScore W2040373312C41625074 @default.
- W2040373312 hasConceptScore W2040373312C55493867 @default.
- W2040373312 hasConceptScore W2040373312C57600042 @default.
- W2040373312 hasConceptScore W2040373312C71924100 @default.
- W2040373312 hasConceptScore W2040373312C86803240 @default.
- W2040373312 hasIssue "11" @default.
- W2040373312 hasLocation W20403733121 @default.
- W2040373312 hasLocation W20403733122 @default.
- W2040373312 hasLocation W20403733123 @default.
- W2040373312 hasLocation W20403733124 @default.
- W2040373312 hasOpenAccess W2040373312 @default.
- W2040373312 hasPrimaryLocation W20403733121 @default.
- W2040373312 hasRelatedWork W1974022140 @default.
- W2040373312 hasRelatedWork W1975119431 @default.
- W2040373312 hasRelatedWork W1991646755 @default.
- W2040373312 hasRelatedWork W2007509030 @default.
- W2040373312 hasRelatedWork W2028882498 @default.
- W2040373312 hasRelatedWork W2062608354 @default.
- W2040373312 hasRelatedWork W2105843079 @default.
- W2040373312 hasRelatedWork W2411792138 @default.
- W2040373312 hasRelatedWork W4239208513 @default.
- W2040373312 hasRelatedWork W60684578 @default.
- W2040373312 hasVolume "93" @default.
- W2040373312 isParatext "false" @default.
- W2040373312 isRetracted "false" @default.
- W2040373312 magId "2040373312" @default.
- W2040373312 workType "article" @default.