Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040373623> ?p ?o ?g. }
- W2040373623 endingPage "163" @default.
- W2040373623 startingPage "153" @default.
- W2040373623 abstract "Elevated β-catenin levels in human colorectal cancer (CRC) cells lead to increased trans-activation of ‘protumorigenic’ β-catenin/T-cell factor (TCF) target genes such as cyclin D1. Therefore, possible targets for the anti-CRC activity of nonsteroidal anti-inflammatory drugs (NSAIDs) are β-catenin and catenin-related transcription (CRT). We tested the antiproliferative activity and the effects on levels of β-catenin and cyclin D1 protein, as well as CRT (measured using a synthetic β-catenin/TCF-reporter gene [TOPflash]), of a panel of NSAIDs (indomethacin, diclofenac, sulindac sulphide and sulphone, rofecoxib; range 10–600 μM) on SW480 human CRC cells in vitro. Following NSAID treatment, there was no consistent relationship between reduced cell proliferation, induction of apoptosis and changes in β-catenin protein levels or CRT. All the NSAIDs, except rofecoxib, decreased nuclear β-catenin content and cyclin D1 protein levels in parallel with their antiproliferative activity. However, cyclin D1 downregulation occurred prior to a decrease in total β-catenin protein levels and there was no correlation with changes in CRT, suggesting the existence of CRT-independent effects of NSAIDs on cyclin D1 expression. In summary, NSAIDs have differential effects on β-catenin protein and CRT, which are unlikely to fully explain their effects on cyclin D1 and their antiproliferative activity on human CRC cells in vitro." @default.
- W2040373623 created "2016-06-24" @default.
- W2040373623 creator A5046921558 @default.
- W2040373623 creator A5059507305 @default.
- W2040373623 creator A5069417785 @default.
- W2040373623 date "2004-06-08" @default.
- W2040373623 modified "2023-10-07" @default.
- W2040373623 title "Effect of nonsteroidal anti-inflammatory drugs on β-catenin protein levels and catenin-related transcription in human colorectal cancer cells" @default.
- W2040373623 cites W140965324 @default.
- W2040373623 cites W1607842260 @default.
- W2040373623 cites W1777065333 @default.
- W2040373623 cites W1876192519 @default.
- W2040373623 cites W1898755691 @default.
- W2040373623 cites W1965613466 @default.
- W2040373623 cites W1996174176 @default.
- W2040373623 cites W2005168722 @default.
- W2040373623 cites W2007251848 @default.
- W2040373623 cites W2024854831 @default.
- W2040373623 cites W2026650776 @default.
- W2040373623 cites W2033387723 @default.
- W2040373623 cites W2038410983 @default.
- W2040373623 cites W2045574895 @default.
- W2040373623 cites W2049821512 @default.
- W2040373623 cites W2062861788 @default.
- W2040373623 cites W2087824838 @default.
- W2040373623 cites W2095715712 @default.
- W2040373623 cites W2108944718 @default.
- W2040373623 cites W2109069210 @default.
- W2040373623 cites W2111303192 @default.
- W2040373623 cites W2118472471 @default.
- W2040373623 cites W2122953993 @default.
- W2040373623 cites W2126003029 @default.
- W2040373623 cites W2142779171 @default.
- W2040373623 cites W2144544309 @default.
- W2040373623 cites W2146167376 @default.
- W2040373623 cites W2147433377 @default.
- W2040373623 cites W2156881931 @default.
- W2040373623 cites W2160971992 @default.
- W2040373623 cites W2166137435 @default.
- W2040373623 cites W2166295460 @default.
- W2040373623 cites W2171978272 @default.
- W2040373623 cites W2323332126 @default.
- W2040373623 cites W2330496155 @default.
- W2040373623 doi "https://doi.org/10.1038/sj.bjc.6601901" @default.
- W2040373623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2364748" @default.
- W2040373623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15188006" @default.
- W2040373623 hasPublicationYear "2004" @default.
- W2040373623 type Work @default.
- W2040373623 sameAs 2040373623 @default.
- W2040373623 citedByCount "50" @default.
- W2040373623 countsByYear W20403736232012 @default.
- W2040373623 countsByYear W20403736232013 @default.
- W2040373623 countsByYear W20403736232014 @default.
- W2040373623 countsByYear W20403736232015 @default.
- W2040373623 countsByYear W20403736232016 @default.
- W2040373623 countsByYear W20403736232017 @default.
- W2040373623 countsByYear W20403736232019 @default.
- W2040373623 crossrefType "journal-article" @default.
- W2040373623 hasAuthorship W2040373623A5046921558 @default.
- W2040373623 hasAuthorship W2040373623A5059507305 @default.
- W2040373623 hasAuthorship W2040373623A5069417785 @default.
- W2040373623 hasBestOaLocation W20403736231 @default.
- W2040373623 hasConcept C11882975 @default.
- W2040373623 hasConcept C121608353 @default.
- W2040373623 hasConcept C126322002 @default.
- W2040373623 hasConcept C137620995 @default.
- W2040373623 hasConcept C181199279 @default.
- W2040373623 hasConcept C185592680 @default.
- W2040373623 hasConcept C190283241 @default.
- W2040373623 hasConcept C199835354 @default.
- W2040373623 hasConcept C2776241388 @default.
- W2040373623 hasConcept C2778484676 @default.
- W2040373623 hasConcept C2778582115 @default.
- W2040373623 hasConcept C2779689624 @default.
- W2040373623 hasConcept C29537977 @default.
- W2040373623 hasConcept C30145163 @default.
- W2040373623 hasConcept C502942594 @default.
- W2040373623 hasConcept C526805850 @default.
- W2040373623 hasConcept C55493867 @default.
- W2040373623 hasConcept C62112901 @default.
- W2040373623 hasConcept C62478195 @default.
- W2040373623 hasConcept C71924100 @default.
- W2040373623 hasConcept C98274493 @default.
- W2040373623 hasConceptScore W2040373623C11882975 @default.
- W2040373623 hasConceptScore W2040373623C121608353 @default.
- W2040373623 hasConceptScore W2040373623C126322002 @default.
- W2040373623 hasConceptScore W2040373623C137620995 @default.
- W2040373623 hasConceptScore W2040373623C181199279 @default.
- W2040373623 hasConceptScore W2040373623C185592680 @default.
- W2040373623 hasConceptScore W2040373623C190283241 @default.
- W2040373623 hasConceptScore W2040373623C199835354 @default.
- W2040373623 hasConceptScore W2040373623C2776241388 @default.
- W2040373623 hasConceptScore W2040373623C2778484676 @default.
- W2040373623 hasConceptScore W2040373623C2778582115 @default.
- W2040373623 hasConceptScore W2040373623C2779689624 @default.
- W2040373623 hasConceptScore W2040373623C29537977 @default.
- W2040373623 hasConceptScore W2040373623C30145163 @default.
- W2040373623 hasConceptScore W2040373623C502942594 @default.