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- W2040374089 abstract "The ventrolateral orbital cortex (VLO) is a component of an endogenous analgesic system consisting of an ascending pathway from the spinal cord to VLO via the thalamic nucleus submedius (Sm) and a descending pathway relaying in the periaqueductal gray matter (PAG). This study examines whether the activation of 5-HT1A receptors in VLO produces antinociception and whether GABAergic modulation is involved in the VLO 5-HT1A receptor activation-evoked antinociception. The radiant heat-evoked tail flick (TF) reflex was used as an index of nociceptive response in lightly anesthetized rats. Microinjection of the 5-HT1A receptor agonist 8-OH-DPAT (1.0, 2.0, 5.0 μg) into VLO produced dose-dependent antinociception, which was reversed by the 5-HT1A receptor antagonist (NAN-190, 20 μg). We also found that VLO application of the GABAA receptor antagonist bicuculline or picrotoxin (100 ng) enhanced the 8-OH-DPAT-induced inhibition of the TF reflex, whereas the GABAA receptor agonist muscimol (250 ng) or THIP (1.0 μg) significantly attenuated the 8-OH-DPAT-induced inhibition. These results suggest that 5-HT1A receptors are involved in VLO-induced antinociception and that GABAergic disinhibitory mechanisms participate in the 5-HT1A receptor-mediated effect. These findings provide support for the hypothesis that 5-HT1A receptor activation may inhibit the inhibitory action of the GABAergic interneurons on the output neurons projecting to PAG leading to activation of the brainstem descending inhibitory system and depression of nociceptive inputs at the spinal cord level." @default.
- W2040374089 created "2016-06-24" @default.
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- W2040374089 date "2008-10-15" @default.
- W2040374089 modified "2023-10-16" @default.
- W2040374089 title "GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT1A receptor activation-induced antinociception in the rat" @default.
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- W2040374089 doi "https://doi.org/10.1016/j.pain.2008.05.013" @default.
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