Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040374420> ?p ?o ?g. }
- W2040374420 abstract "Significance Many proteins solved by Structural Genomics have low sequence identity to other proteins and cannot be assigned functions. To address this problem, we present a computational approach that creates structural motifs of a few evolutionarily important residues, and these motifs probe local geometric and evolutionary similarities in other protein structures to detect functional similarities. This approach does not require prior knowledge of functional mechanisms and is highly accurate in computational benchmarks when annotations rely on homologs with low sequence identity. We further demonstrate the accuracy of this approach using biochemical and mutagenesis studies to validate two predictions of unannotated proteins." @default.
- W2040374420 created "2016-06-24" @default.
- W2040374420 creator A5019002928 @default.
- W2040374420 creator A5023680746 @default.
- W2040374420 creator A5044814535 @default.
- W2040374420 creator A5066088237 @default.
- W2040374420 creator A5083076717 @default.
- W2040374420 date "2013-10-21" @default.
- W2040374420 modified "2023-10-15" @default.
- W2040374420 title "Prediction and experimental validation of enzyme substrate specificity in protein structures" @default.
- W2040374420 cites W1542561015 @default.
- W2040374420 cites W1575826900 @default.
- W2040374420 cites W1580328099 @default.
- W2040374420 cites W1952750972 @default.
- W2040374420 cites W1964640688 @default.
- W2040374420 cites W1965533615 @default.
- W2040374420 cites W1968195251 @default.
- W2040374420 cites W1971099088 @default.
- W2040374420 cites W1974499817 @default.
- W2040374420 cites W1975316279 @default.
- W2040374420 cites W1975563330 @default.
- W2040374420 cites W1977785419 @default.
- W2040374420 cites W1982168039 @default.
- W2040374420 cites W1990598130 @default.
- W2040374420 cites W1990767517 @default.
- W2040374420 cites W1992115216 @default.
- W2040374420 cites W1993717649 @default.
- W2040374420 cites W1998014636 @default.
- W2040374420 cites W2006512809 @default.
- W2040374420 cites W2006538659 @default.
- W2040374420 cites W2007933226 @default.
- W2040374420 cites W2007978853 @default.
- W2040374420 cites W2008708467 @default.
- W2040374420 cites W2015147525 @default.
- W2040374420 cites W2019523557 @default.
- W2040374420 cites W2024620705 @default.
- W2040374420 cites W2035077602 @default.
- W2040374420 cites W2039290542 @default.
- W2040374420 cites W2047620716 @default.
- W2040374420 cites W2048947602 @default.
- W2040374420 cites W2049381178 @default.
- W2040374420 cites W2053159677 @default.
- W2040374420 cites W2054618890 @default.
- W2040374420 cites W2057387739 @default.
- W2040374420 cites W2061750017 @default.
- W2040374420 cites W2062475405 @default.
- W2040374420 cites W2063040036 @default.
- W2040374420 cites W2067949684 @default.
- W2040374420 cites W2071610232 @default.
- W2040374420 cites W2073255933 @default.
- W2040374420 cites W2084200259 @default.
- W2040374420 cites W2088223052 @default.
- W2040374420 cites W2088534163 @default.
- W2040374420 cites W2092053194 @default.
- W2040374420 cites W2092318974 @default.
- W2040374420 cites W2095298573 @default.
- W2040374420 cites W2096739999 @default.
- W2040374420 cites W2099389777 @default.
- W2040374420 cites W2100242429 @default.
- W2040374420 cites W2100320834 @default.
- W2040374420 cites W2101780178 @default.
- W2040374420 cites W2102245393 @default.
- W2040374420 cites W2103310202 @default.
- W2040374420 cites W2104812418 @default.
- W2040374420 cites W2110115297 @default.
- W2040374420 cites W2115595474 @default.
- W2040374420 cites W2117164735 @default.
- W2040374420 cites W2120651379 @default.
- W2040374420 cites W2121704271 @default.
- W2040374420 cites W2123858481 @default.
- W2040374420 cites W2124071595 @default.
- W2040374420 cites W2125546020 @default.
- W2040374420 cites W2125725340 @default.
- W2040374420 cites W2126257927 @default.
- W2040374420 cites W2130479394 @default.
- W2040374420 cites W2137015675 @default.
- W2040374420 cites W2137991504 @default.
- W2040374420 cites W2144258433 @default.
- W2040374420 cites W2144477832 @default.
- W2040374420 cites W2146939455 @default.
- W2040374420 cites W2153095859 @default.
- W2040374420 cites W2154715418 @default.
- W2040374420 cites W2156728093 @default.
- W2040374420 cites W2158714788 @default.
- W2040374420 cites W2162220273 @default.
- W2040374420 cites W2162574056 @default.
- W2040374420 cites W2163828755 @default.
- W2040374420 cites W2166278492 @default.
- W2040374420 cites W2169575504 @default.
- W2040374420 cites W2169834479 @default.
- W2040374420 cites W2171172158 @default.
- W2040374420 cites W2338184220 @default.
- W2040374420 cites W4211208250 @default.
- W2040374420 cites W4243003303 @default.
- W2040374420 doi "https://doi.org/10.1073/pnas.1305162110" @default.
- W2040374420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3831482" @default.
- W2040374420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24145433" @default.
- W2040374420 hasPublicationYear "2013" @default.
- W2040374420 type Work @default.
- W2040374420 sameAs 2040374420 @default.