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• W2040375086 abstract "Platinum-containing chemotherapy agents (cisplatin, carboplatin, oxaliplatin) have been approved in the first-line setting of numerous malignancies, such as ovarian, bladder, head and neck, colorectal, and lung cancer. Their extensive use over the last decade has led to a significant increase in the incidence of hypersensitivity reactions, which are defined as unforeseen reactions whose signs and symptoms cannot be explained by the known toxicity of these drugs. Skin rash, flushing, abdominal cramping, itchy palms, and back pain are common symptoms. Cardiovascular and respiratory complications can prove fatal. Multiple pathogenetic mechanisms have been suggested. Hypersensitivity usually appears after multiple infusions, suggesting type I allergic reactions; however, other types of hypersensitivity also seem to be implicated. Several management options are available to treating physicians: discontinuation of chemotherapy, premedication, prolonging of infusion duration, desensitization protocols, and replacement with a different platinum compound after performing skin tests that rule out cross-reactions among platinum agents." @default.
• W2040375086 created "2016-06-24" @default.
• W2040375086 creator A5001509678 @default.
• W2040375086 creator A5017492413 @default.
• W2040375086 creator A5038751972 @default.
• W2040375086 creator A5052002873 @default.
• W2040375086 creator A5070561439 @default.
• W2040375086 date "2010-09-20" @default.
• W2040375086 modified "2023-10-16" @default.
• W2040375086 title "Hypersensitivity Reactions Associated with Platinum Antineoplastic Agents: A Systematic Review" @default.
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