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- W2040375567 endingPage "737" @default.
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- W2040375567 abstract "The arcuate nucleus (ARC) of the hypothalamus is particularly regarded as a critical platform that integrates circulating signals of hunger and satiety reflecting energy stores and nutrient availability. Among ARC neurons, pro-opiomelanocortin (POMC) and agouti-related protein and neuropeptide Y (NPY/AgRP neurons) are considered as two opposing branches of the melanocortin signaling pathway. Integration of circulating signals of hunger and satiety results in the release of the melanocortin receptor ligand α-melanocyte-stimulating hormone (αMSH) by the POMC neurons system and decreases feeding and increases energy expenditure. The orexigenic/anabolic action of NPY/AgRP neurons is believed to rely essentially on their inhibitory input onto POMC neurons and second-orders targets. Recent updates in the field have casted a new light on the role of the ARC neurons in the coordinated regulation of peripheral organs involved in the control of nutrient storage, transformation and substrate utilization independent of food intake." @default.
- W2040375567 created "2016-06-24" @default.
- W2040375567 creator A5007928374 @default.
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- W2040375567 creator A5034986738 @default.
- W2040375567 creator A5050445319 @default.
- W2040375567 creator A5053645783 @default.
- W2040375567 creator A5077498830 @default.
- W2040375567 date "2014-10-01" @default.
- W2040375567 modified "2023-10-14" @default.
- W2040375567 title "The hypothalamic arcuate nucleus and the control of peripheral substrates" @default.
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