Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040376006> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2040376006 endingPage "695" @default.
- W2040376006 startingPage "688" @default.
- W2040376006 abstract "We conducted an exploratory, post hoc, subgroup analysis of the East Asian (EA) patients in a multinational phase III trial to determine whether the efficacy results for this subgroup were consistent with those observed for the entire study population.Thousand seven hundred twenty-five patients with advanced non-small cell lung cancer (NSCLC), including 126 EA patients (7.3%) from Taiwan and Korea, were enrolled in the trial and randomly assigned first-line chemotherapy with cisplatin and pemetrexed (CP; n = 862) or cisplatin and gemcitabine (CG; n = 863). Adjusted Cox proportional hazards models were used to compare overall survival and progression-free survival between the treatment arms in the EA subgroup. Median time-to-event data were estimated with the Kaplan-Meier method.Consistent with the results for the entire study population, survival in the EA subgroup trended in favor of CP over CG in patients with non-squamous histology, despite the more frequent use of post discontinuation targeted therapy in the CG arm. The opposite trend was noted for patients with squamous tumors. A higher proportion of patients in the EA subgroup were never smokers compared with the entire study population. A trend toward improved survival with CP compared with CG was seen regardless of smoking status, particularly in non-squamous patients.The key finding of this subgroup analysis was that the NSCLC histology effect on treatment outcomes for pemetrexed-treated patients seen in the entire study population was also apparent in the EA subgroup. The potential prognostic influence of race, histology subtype, and smoking status should be assessed in future NSCLC studies." @default.
- W2040376006 created "2016-06-24" @default.
- W2040376006 creator A5028033679 @default.
- W2040376006 creator A5030107272 @default.
- W2040376006 creator A5052962058 @default.
- W2040376006 creator A5055974749 @default.
- W2040376006 creator A5079802303 @default.
- W2040376006 creator A5087644129 @default.
- W2040376006 date "2010-05-01" @default.
- W2040376006 modified "2023-09-25" @default.
- W2040376006 title "Efficacy and Safety of Cisplatin/Pemetrexed Versus Cisplatin/Gemcitabine as First-Line Treatment in East Asian Patients with Advanced Non-small Cell Lung Cancer: Results of an Exploratory Subgroup Analysis of a Phase III Trial" @default.
- W2040376006 cites W1985329793 @default.
- W2040376006 cites W1998387441 @default.
- W2040376006 cites W2012248028 @default.
- W2040376006 cites W2022950401 @default.
- W2040376006 cites W2027737109 @default.
- W2040376006 cites W2058592399 @default.
- W2040376006 cites W2065223314 @default.
- W2040376006 cites W2069422280 @default.
- W2040376006 cites W2070927612 @default.
- W2040376006 cites W2079419271 @default.
- W2040376006 cites W2099725888 @default.
- W2040376006 cites W2134667653 @default.
- W2040376006 cites W2138297714 @default.
- W2040376006 cites W2139248078 @default.
- W2040376006 cites W2139939379 @default.
- W2040376006 cites W2145238269 @default.
- W2040376006 cites W2145653040 @default.
- W2040376006 cites W2168996492 @default.
- W2040376006 doi "https://doi.org/10.1097/jto.0b013e3181d1273d" @default.
- W2040376006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20150825" @default.
- W2040376006 hasPublicationYear "2010" @default.
- W2040376006 type Work @default.
- W2040376006 sameAs 2040376006 @default.
- W2040376006 citedByCount "45" @default.
- W2040376006 countsByYear W20403760062012 @default.
- W2040376006 countsByYear W20403760062013 @default.
- W2040376006 countsByYear W20403760062014 @default.
- W2040376006 countsByYear W20403760062015 @default.
- W2040376006 countsByYear W20403760062016 @default.
- W2040376006 countsByYear W20403760062017 @default.
- W2040376006 countsByYear W20403760062018 @default.
- W2040376006 countsByYear W20403760062019 @default.
- W2040376006 countsByYear W20403760062022 @default.
- W2040376006 crossrefType "journal-article" @default.
- W2040376006 hasAuthorship W2040376006A5028033679 @default.
- W2040376006 hasAuthorship W2040376006A5030107272 @default.
- W2040376006 hasAuthorship W2040376006A5052962058 @default.
- W2040376006 hasAuthorship W2040376006A5055974749 @default.
- W2040376006 hasAuthorship W2040376006A5079802303 @default.
- W2040376006 hasAuthorship W2040376006A5087644129 @default.
- W2040376006 hasBestOaLocation W20403760061 @default.
- W2040376006 hasConcept C126322002 @default.
- W2040376006 hasConcept C143998085 @default.
- W2040376006 hasConcept C187960798 @default.
- W2040376006 hasConcept C2776256026 @default.
- W2040376006 hasConcept C2776694085 @default.
- W2040376006 hasConcept C2777240266 @default.
- W2040376006 hasConcept C2778239845 @default.
- W2040376006 hasConcept C2780258809 @default.
- W2040376006 hasConcept C2908647359 @default.
- W2040376006 hasConcept C44249647 @default.
- W2040376006 hasConcept C71924100 @default.
- W2040376006 hasConcept C99454951 @default.
- W2040376006 hasConceptScore W2040376006C126322002 @default.
- W2040376006 hasConceptScore W2040376006C143998085 @default.
- W2040376006 hasConceptScore W2040376006C187960798 @default.
- W2040376006 hasConceptScore W2040376006C2776256026 @default.
- W2040376006 hasConceptScore W2040376006C2776694085 @default.
- W2040376006 hasConceptScore W2040376006C2777240266 @default.
- W2040376006 hasConceptScore W2040376006C2778239845 @default.
- W2040376006 hasConceptScore W2040376006C2780258809 @default.
- W2040376006 hasConceptScore W2040376006C2908647359 @default.
- W2040376006 hasConceptScore W2040376006C44249647 @default.
- W2040376006 hasConceptScore W2040376006C71924100 @default.
- W2040376006 hasConceptScore W2040376006C99454951 @default.
- W2040376006 hasIssue "5" @default.
- W2040376006 hasLocation W20403760061 @default.
- W2040376006 hasLocation W20403760062 @default.
- W2040376006 hasOpenAccess W2040376006 @default.
- W2040376006 hasPrimaryLocation W20403760061 @default.
- W2040376006 hasRelatedWork W1969723679 @default.
- W2040376006 hasRelatedWork W1971570522 @default.
- W2040376006 hasRelatedWork W2079203038 @default.
- W2040376006 hasRelatedWork W2100029565 @default.
- W2040376006 hasRelatedWork W2136403887 @default.
- W2040376006 hasRelatedWork W2385793487 @default.
- W2040376006 hasRelatedWork W2386165131 @default.
- W2040376006 hasRelatedWork W2977610808 @default.
- W2040376006 hasRelatedWork W4250822077 @default.
- W2040376006 hasRelatedWork W4254666574 @default.
- W2040376006 hasVolume "5" @default.
- W2040376006 isParatext "false" @default.
- W2040376006 isRetracted "false" @default.
- W2040376006 magId "2040376006" @default.
- W2040376006 workType "article" @default.