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• W2040376018 abstract "Junctional Adhesion Molecules (JAMs) are components and regulators of the well-characterized epithelial and endothelial tight junction. Since the molecular components of native fibroblast adherens-like junctions remain poorly described we determined JAM expression profiles in fibroblasts. We found JAM-C on human dermal, lung, and corneal primary fibroblast cultures. Within murine lines, JAM-A was found in L-cells, JAM-C in 3T3 L1 cells, and both JAM-A and JAM-C were co-expressed in NIH 3T3 fibroblasts. In primary dermal fibroblasts, JAM-C concentrated at zipper-like junctions that formed between apposing cells. Dual immunostaining showed JAM-C co-localization with the ZO-1 intracellular scaffolding molecule at cell contacts that ranged from 7 microm to over 25 microm in length. JAM-C also labeled similar zipper-like junctions detected with N-Cadherin and Cadherin-11 antibodies. We conclude that endogenous JAM-C is an integral component of the dermal fibroblast adherens-like junction, and our data extend the expression and potential function of JAMs into mesenchymal tissues." @default.
• W2040376018 created "2016-06-24" @default.
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• W2040376018 date "2006-01-01" @default.
• W2040376018 modified "2023-10-01" @default.
• W2040376018 title "Junctional Adhesion Molecules (JAMs) are Differentially Expressed in Fibroblasts and Co-Localize with ZO-1 to Adherens-Like Junctions" @default.
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• W2040376018 doi "https://doi.org/10.1080/15419060600877978" @default.
• W2040376018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16916751" @default.
• W2040376018 hasPublicationYear "2006" @default.
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