Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040379417> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2040379417 endingPage "114" @default.
- W2040379417 startingPage "107" @default.
- W2040379417 abstract "Both 1,2-naphthoquinone (1,2-NPQ) and 1,4-naphthoquinone (1,4-NPQ) are reactive metabolites of naphthalene that are thought to be responsible for the naphthalene-induced cytotoxicity and genotoxicity. The aim of this study was to investigate the cumulative tissue dose of 1,2-NPQ and 1,4-NPQ in human serum derived from blood donors in Taiwan via measurements of albumin adducts by a methodology, which employs trifluoroacetic acid anhydride and methanesulfonic acid to selectively cleave cysteinyl adducts on proteins. Both 1,2-NPQ and 1,4-NPQ adducts were detected in all male and female subjects (n=22). The median levels of 1,2-NPQ adduct in human subjects were estimated to be 268 (range 139-857) and 203 (range 128-1352) (pmol/g) in male (n=11) and female (n=11) subjects, respectively. In contrast, the median levels of 1,4-NPQ adduct were estimated to be 45.0 (range 22.0-117) and 38.9 (range 21.5-172) (pmol/g) in male and female subjects, respectively. We noticed that levels of 1,2-NPQ adduct were significantly correlated with those of 1,4-NPQ adduct (correlation coefficient r=0.643, p<0.01). Results from in vitro experiments confirmed that the production of naphthoquinones-derived adducts on serum albumin increased with increased concentration of naphthoquinones (0-100 microM). Linear relationships were observed over the range of concentration. Time-course experiments suggested that both 1,2-NPQ and 1,4-NPQ-derived adducts rapidly reached maximum values at 10 min mark and remained constant thereafter. The reaction rate constant analyses indicated that the second-order rate constants, representing in vitro reactions between naphthoquinones and cysteine residues of serum albumin, were estimated to be 0.0044/0.0002L(gprotein)(-1)h(-1), respectively. Overall, the cumulative tissue doses of 1,4-NPQ (217-316 nM h) in male and female subjects were approximately 3-fold greater than those of 1,2-NPQ (76-98 nM h) in the study population. The initial concentrations of serum 1,2-NPQ and 1,4-NPQ in the study population were estimated to be between 145-188 and 807-1175 nM, respectively. We conclude that the relatively large amounts of naphthoquinones present in human serum may point to toxicological consequences." @default.
- W2040379417 created "2016-06-24" @default.
- W2040379417 creator A5018048892 @default.
- W2040379417 creator A5044369023 @default.
- W2040379417 creator A5056510914 @default.
- W2040379417 creator A5066515598 @default.
- W2040379417 creator A5087472198 @default.
- W2040379417 date "2009-09-01" @default.
- W2040379417 modified "2023-10-01" @default.
- W2040379417 title "Investigation of the cumulative tissue doses of naphthoquinones in human serum using protein adducts as biomarker of exposure" @default.
- W2040379417 cites W1973976348 @default.
- W2040379417 cites W1977488914 @default.
- W2040379417 cites W1979661519 @default.
- W2040379417 cites W1981211406 @default.
- W2040379417 cites W1995069658 @default.
- W2040379417 cites W2003138509 @default.
- W2040379417 cites W2012499156 @default.
- W2040379417 cites W2016930491 @default.
- W2040379417 cites W2029801192 @default.
- W2040379417 cites W2032153758 @default.
- W2040379417 cites W2034584551 @default.
- W2040379417 cites W2034630856 @default.
- W2040379417 cites W2038858817 @default.
- W2040379417 cites W2061619211 @default.
- W2040379417 cites W2069471046 @default.
- W2040379417 cites W2080258692 @default.
- W2040379417 cites W2089038620 @default.
- W2040379417 cites W2090990681 @default.
- W2040379417 cites W2099253121 @default.
- W2040379417 cites W2131553001 @default.
- W2040379417 cites W2144516528 @default.
- W2040379417 cites W2150530716 @default.
- W2040379417 cites W2164020825 @default.
- W2040379417 cites W2165172263 @default.
- W2040379417 cites W2195382830 @default.
- W2040379417 cites W308394836 @default.
- W2040379417 doi "https://doi.org/10.1016/j.cbi.2009.05.016" @default.
- W2040379417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19505452" @default.
- W2040379417 hasPublicationYear "2009" @default.
- W2040379417 type Work @default.
- W2040379417 sameAs 2040379417 @default.
- W2040379417 citedByCount "17" @default.
- W2040379417 countsByYear W20403794172012 @default.
- W2040379417 countsByYear W20403794172014 @default.
- W2040379417 countsByYear W20403794172015 @default.
- W2040379417 countsByYear W20403794172016 @default.
- W2040379417 countsByYear W20403794172017 @default.
- W2040379417 countsByYear W20403794172018 @default.
- W2040379417 countsByYear W20403794172019 @default.
- W2040379417 countsByYear W20403794172020 @default.
- W2040379417 countsByYear W20403794172022 @default.
- W2040379417 countsByYear W20403794172023 @default.
- W2040379417 crossrefType "journal-article" @default.
- W2040379417 hasAuthorship W2040379417A5018048892 @default.
- W2040379417 hasAuthorship W2040379417A5044369023 @default.
- W2040379417 hasAuthorship W2040379417A5056510914 @default.
- W2040379417 hasAuthorship W2040379417A5066515598 @default.
- W2040379417 hasAuthorship W2040379417A5087472198 @default.
- W2040379417 hasConcept C108204754 @default.
- W2040379417 hasConcept C178790620 @default.
- W2040379417 hasConcept C185592680 @default.
- W2040379417 hasConcept C2776125364 @default.
- W2040379417 hasConcept C2776792860 @default.
- W2040379417 hasConcept C55493867 @default.
- W2040379417 hasConceptScore W2040379417C108204754 @default.
- W2040379417 hasConceptScore W2040379417C178790620 @default.
- W2040379417 hasConceptScore W2040379417C185592680 @default.
- W2040379417 hasConceptScore W2040379417C2776125364 @default.
- W2040379417 hasConceptScore W2040379417C2776792860 @default.
- W2040379417 hasConceptScore W2040379417C55493867 @default.
- W2040379417 hasIssue "1" @default.
- W2040379417 hasLocation W20403794171 @default.
- W2040379417 hasLocation W20403794172 @default.
- W2040379417 hasOpenAccess W2040379417 @default.
- W2040379417 hasPrimaryLocation W20403794171 @default.
- W2040379417 hasRelatedWork W1991616557 @default.
- W2040379417 hasRelatedWork W2016472295 @default.
- W2040379417 hasRelatedWork W2026948689 @default.
- W2040379417 hasRelatedWork W2047991101 @default.
- W2040379417 hasRelatedWork W2334792521 @default.
- W2040379417 hasRelatedWork W2341880960 @default.
- W2040379417 hasRelatedWork W2951300725 @default.
- W2040379417 hasRelatedWork W2951566524 @default.
- W2040379417 hasRelatedWork W2953125259 @default.
- W2040379417 hasRelatedWork W2953291986 @default.
- W2040379417 hasVolume "181" @default.
- W2040379417 isParatext "false" @default.
- W2040379417 isRetracted "false" @default.
- W2040379417 magId "2040379417" @default.
- W2040379417 workType "article" @default.