FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040380614> ?p ?o ?g. }

• W2040380614 endingPage "1438" @default.
• W2040380614 startingPage "1433" @default.
• W2040380614 abstract "Nonsteroidal anti-inflammatory drugs (NSAIDs) are a mainstay in the treatment of inflammatory disease and are among the most widely used drugs worldwide. They are anti-inflammatory, antipyretic, and analgesic and are prescribed as first choice for the treatment of rheumatic disorders and, in general, inflammation. The main limitation in using NSAIDs consists in their side-effects, including gastrointestinal ulcerogenic activity and bronchospasm. The mechanism of action of these drugs is attributed to the inhibition of cyclooxygenase (COX), and, consequently, the conversion of arachidonic acid into prostaglandins. It is hypothesized that the undesirable side-effects of NSAIDs are due to the inhibition of COX-1 (constitutive isoform), whereas the beneficial effects are related to the inhibition of COX-2 (inducible isoform). Arachidonic acid can also be converted to leukotrienes (LTs) by the action of 5-lipoxygenase (5-LOX). LTC(4,) LTD(4,) and LTE(4) are potent bronchoconstrictors, whereas LTB(4) is chemotactic for leukocytes and plays an important role in the development of gastrointestinal ulcers by contributing to the inflammatory process. Thus, developing dual inhibitor compounds that will simultaneously inhibit COX and 5-LOX could enhance their individual anti-inflammatory effects and reduce the undesirable side-effects associated with NSAIDs, especially of the gastrointestinal tract. The most promising COX/5-LOX inhibitor is ML3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid), now in Phase III clinical trials. This new approach will certainly help to unravel the mechanisms at the root of the undesirable effects of NSAIDs and to develop safer NSAIDs." @default.
• W2040380614 created "2016-06-24" @default.
• W2040380614 creator A5016113649 @default.
• W2040380614 creator A5033436256 @default.
• W2040380614 creator A5057720130 @default.
• W2040380614 creator A5066988395 @default.
• W2040380614 date "2001-12-01" @default.
• W2040380614 modified "2023-10-02" @default.
• W2040380614 title "Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy? 1 1Abbreviations: NSAIDs, nonsteroidal anti-inflammatory drugs; COX, cyclooxygenase; LT, leukotriene; 5-LOX, 5-lipoxygenase; PG, prostaglandin; DFU, 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsuphonyl)-phenyl-2(5H)-furanone; and DFP, diisopropyl fluorophosphate." @default.
• W2040380614 cites W1022151459 @default.
• W2040380614 cites W122911005 @default.
• W2040380614 cites W1511945572 @default.
• W2040380614 cites W1541497386 @default.
• W2040380614 cites W1671834350 @default.
• W2040380614 cites W1968991401 @default.
• W2040380614 cites W1971389850 @default.
• W2040380614 cites W1974450761 @default.
• W2040380614 cites W1978368476 @default.
• W2040380614 cites W1980832959 @default.
• W2040380614 cites W1994952794 @default.
• W2040380614 cites W1997208118 @default.
• W2040380614 cites W2001193292 @default.
• W2040380614 cites W2001239671 @default.
• W2040380614 cites W2004065216 @default.
• W2040380614 cites W2004293605 @default.
• W2040380614 cites W2007439586 @default.
• W2040380614 cites W2008424322 @default.
• W2040380614 cites W2008574207 @default.
• W2040380614 cites W2009921418 @default.
• W2040380614 cites W2011793087 @default.
• W2040380614 cites W2012810767 @default.
• W2040380614 cites W2014990551 @default.
• W2040380614 cites W2021364950 @default.
• W2040380614 cites W2023213942 @default.
• W2040380614 cites W2024065712 @default.
• W2040380614 cites W2024176341 @default.
• W2040380614 cites W2024608254 @default.
• W2040380614 cites W2038199642 @default.
• W2040380614 cites W2038410983 @default.
• W2040380614 cites W2039095456 @default.
• W2040380614 cites W2042214933 @default.
• W2040380614 cites W2052031498 @default.
• W2040380614 cites W2052082416 @default.
• W2040380614 cites W2054883739 @default.
• W2040380614 cites W2069708591 @default.
• W2040380614 cites W2071546853 @default.
• W2040380614 cites W2080663864 @default.
• W2040380614 cites W2093731034 @default.
• W2040380614 cites W2105735510 @default.
• W2040380614 cites W2106234499 @default.
• W2040380614 cites W2116105539 @default.
• W2040380614 cites W2117227343 @default.
• W2040380614 cites W2117558614 @default.
• W2040380614 cites W2125471714 @default.
• W2040380614 cites W2134732424 @default.
• W2040380614 cites W2159973565 @default.
• W2040380614 cites W2167243592 @default.
• W2040380614 cites W2170049370 @default.
• W2040380614 cites W2215530158 @default.
• W2040380614 cites W4248529472 @default.
• W2040380614 cites W853373939 @default.
• W2040380614 doi "https://doi.org/10.1016/s0006-2952(01)00747-x" @default.
• W2040380614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11728379" @default.
• W2040380614 hasPublicationYear "2001" @default.
• W2040380614 type Work @default.
• W2040380614 sameAs 2040380614 @default.
• W2040380614 citedByCount "255" @default.
• W2040380614 countsByYear W20403806142012 @default.
• W2040380614 countsByYear W20403806142013 @default.
• W2040380614 countsByYear W20403806142014 @default.
• W2040380614 countsByYear W20403806142015 @default.
• W2040380614 countsByYear W20403806142016 @default.
• W2040380614 countsByYear W20403806142017 @default.
• W2040380614 countsByYear W20403806142018 @default.
• W2040380614 countsByYear W20403806142019 @default.
• W2040380614 countsByYear W20403806142020 @default.
• W2040380614 countsByYear W20403806142021 @default.
• W2040380614 countsByYear W20403806142022 @default.
• W2040380614 countsByYear W20403806142023 @default.
• W2040380614 crossrefType "journal-article" @default.
• W2040380614 hasAuthorship W2040380614A5016113649 @default.
• W2040380614 hasAuthorship W2040380614A5033436256 @default.
• W2040380614 hasAuthorship W2040380614A5057720130 @default.
• W2040380614 hasAuthorship W2040380614A5066988395 @default.
• W2040380614 hasConcept C126322002 @default.
• W2040380614 hasConcept C181199279 @default.
• W2040380614 hasConcept C185592680 @default.
• W2040380614 hasConcept C203014093 @default.
• W2040380614 hasConcept C2776042228 @default.
• W2040380614 hasConcept C2776352991 @default.
• W2040380614 hasConcept C2776452501 @default.
• W2040380614 hasConcept C2776685179 @default.
• W2040380614 hasConcept C2776914184 @default.
• W2040380614 hasConcept C2777956040 @default.
• W2040380614 hasConcept C2778078955 @default.
• W2040380614 hasConcept C2779689624 @default.
• W2040380614 hasConcept C2780857362 @default.
• W2040380614 hasConcept C55493867 @default.

• next