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• W2040381337 abstract "A possible side effect of serotonin-enhancing drugs is the serotonin syndrome, which can be lethal. Here we examined possible hypersensitivity to two such drugs, the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) and the atypical opioid tramadol, in mice lacking the genes for both monoamine oxidase A (MAOA) and MAOB. MAOA/B-knockout (KO) mice displayed baseline serotonin syndrome behaviors, and these behavioral responses were highly exaggerated following 5-HTP or tramadol versus baseline and wild-type (WT) littermates. Compared with MAOA/B-WT mice, baseline tissue serotonin levels were increased ∼2.6–3.9-fold in MAOA/B-KO mice. Following 5-HTP, serotonin levels were further increased ∼4.5–6.2-fold in MAOA/B-KO mice. These exaggerated responses are in line with the exaggerated responses following serotonin-enhancing drugs that we previously observed in mice lacking the serotonin transporter (SERT). These findings provide a second genetic mouse model suggestive of possible human vulnerability to the serotonin syndrome in individuals with lesser-expressing MAO or SERT polymorphisms that confer serotonergic system changes." @default.
• W2040381337 created "2016-06-24" @default.
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• W2040381337 date "2012-09-11" @default.
• W2040381337 modified "2023-10-02" @default.
• W2040381337 title "Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans" @default.
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• W2040381337 doi "https://doi.org/10.1038/tpj.2012.35" @default.
• W2040381337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3562558" @default.
• W2040381337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22964922" @default.
• W2040381337 hasPublicationYear "2012" @default.
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