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- W2040381957 abstract "Tau is a microtubule-assocaited protein (MAP) that stabilizes microtubule polymers in vitro and in situ. In the central nervous system, tau has been localized in both axonal and somatodendritic compartments of neurons. However, tau protein is associated with neurofibrillary tangles (NFT) in vulnerable neurons in Alzheimer's disease (AD). Abnormal tau is associated with post-traductional process such as hyperphosphorylation and truncation. Both events are associated to the genesis of paired helical filaments (PHF) of NFT. We used double and triple immunolabelling with a variety ofantibodies raised tauprotein and analyzed by confocal microscopy. We observed that in undifferentiated cells, the immnunoreactivity of antibodies raised against phosphorylated tau AT100 (212–214), pT231 (231), and AD2 (396–404) was found in the nucleus. However, the immunoreactivity of pT231, TG3 and AD2 increased during the cell cycle process: prophase to anaphase, and decreases in cytokinesis phase. Reactivity to AT100, TG3 and pT231 antibobodies was found in the perinuclear area of some neuronal cells named pretangle cells. Those results suggest that the expression of tau protein appears to be associated with various activities, depending on the functional state of the cells. Tau protein in the nucleus may participate in cycling cells and DNA" @default.
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- W2040381957 date "2013-07-01" @default.
- W2040381957 modified "2023-09-27" @default.
- W2040381957 title "P2-064: The tau protein: From physiological to pathological process in Alzheimer's disease" @default.
- W2040381957 doi "https://doi.org/10.1016/j.jalz.2013.05.707" @default.
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