Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040382098> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2040382098 endingPage "1096" @default.
- W2040382098 startingPage "1091" @default.
- W2040382098 abstract "1. Two model substrates for oxidative hepatic enzyme activity, namely hexobarbital and aminopyrine, were simultaneously orally administered to rats, and blood concentrations of the substrates measured by g.l.c.2. The apparent intrinsic clearances of hexobarbital (Cl*int.HB) and of aminopyrine (Cl*int.AM) were correlated in untreated rats, and in rats pretreated with phenobarbital. 3-methylcholanthrene, polychlorinated biphenyls or carbon tetrachloride. Cl*int.HB and Cl*int.AM were both increased by phenobarbital and polychlorinated biphenyl pretreatment. Pretreatment with 3-methylcholanthrene had hardly any effect, and carbon tetrachloride caused a strong diminution of Cl*int.HB and Cl*int.AM.3. When the dose of aminopyrine was decreased, both Cl*int.HB and Cl*int.AM increased. This indicated that the primary metabolite of aminopyrine. monomethylaminopyrine. inhibits cytochrome P-450.4. The correlation coefficient for all clearance data was 0·92 (N = 36). It was concluded that both hexobarbital and aminopyrine are metabolized in vivo by the same or closely related cytochrome P-450 isozymes, and both may be used as model substrates in vivo for metabolic conversions primarily mediated by the major phenobarbital-inducible cytochrome P-450 subspecies." @default.
- W2040382098 created "2016-06-24" @default.
- W2040382098 creator A5027199677 @default.
- W2040382098 creator A5039807398 @default.
- W2040382098 creator A5041013942 @default.
- W2040382098 creator A5077531513 @default.
- W2040382098 creator A5080532944 @default.
- W2040382098 date "1986-01-01" @default.
- W2040382098 modified "2023-09-23" @default.
- W2040382098 title "Correlation between the metabolism of hexobarbital and aminopyrinein vivoin rats" @default.
- W2040382098 cites W1970193833 @default.
- W2040382098 cites W1975212889 @default.
- W2040382098 cites W1999203131 @default.
- W2040382098 cites W2036188322 @default.
- W2040382098 cites W2041096125 @default.
- W2040382098 cites W2050744197 @default.
- W2040382098 cites W2085986330 @default.
- W2040382098 cites W2106274619 @default.
- W2040382098 cites W2112963897 @default.
- W2040382098 cites W2139508000 @default.
- W2040382098 cites W2151201559 @default.
- W2040382098 cites W736251 @default.
- W2040382098 doi "https://doi.org/10.3109/00498258609038986" @default.
- W2040382098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3798956" @default.
- W2040382098 hasPublicationYear "1986" @default.
- W2040382098 type Work @default.
- W2040382098 sameAs 2040382098 @default.
- W2040382098 citedByCount "4" @default.
- W2040382098 crossrefType "journal-article" @default.
- W2040382098 hasAuthorship W2040382098A5027199677 @default.
- W2040382098 hasAuthorship W2040382098A5039807398 @default.
- W2040382098 hasAuthorship W2040382098A5041013942 @default.
- W2040382098 hasAuthorship W2040382098A5077531513 @default.
- W2040382098 hasAuthorship W2040382098A5080532944 @default.
- W2040382098 hasConcept C126322002 @default.
- W2040382098 hasConcept C134018914 @default.
- W2040382098 hasConcept C150903083 @default.
- W2040382098 hasConcept C178790620 @default.
- W2040382098 hasConcept C181199279 @default.
- W2040382098 hasConcept C185592680 @default.
- W2040382098 hasConcept C207001950 @default.
- W2040382098 hasConcept C2777359374 @default.
- W2040382098 hasConcept C2777466164 @default.
- W2040382098 hasConcept C2777477808 @default.
- W2040382098 hasConcept C2778793413 @default.
- W2040382098 hasConcept C2780768313 @default.
- W2040382098 hasConcept C2781109383 @default.
- W2040382098 hasConcept C526171541 @default.
- W2040382098 hasConcept C55493867 @default.
- W2040382098 hasConcept C62231903 @default.
- W2040382098 hasConcept C71924100 @default.
- W2040382098 hasConcept C86803240 @default.
- W2040382098 hasConcept C87644729 @default.
- W2040382098 hasConcept C98274493 @default.
- W2040382098 hasConceptScore W2040382098C126322002 @default.
- W2040382098 hasConceptScore W2040382098C134018914 @default.
- W2040382098 hasConceptScore W2040382098C150903083 @default.
- W2040382098 hasConceptScore W2040382098C178790620 @default.
- W2040382098 hasConceptScore W2040382098C181199279 @default.
- W2040382098 hasConceptScore W2040382098C185592680 @default.
- W2040382098 hasConceptScore W2040382098C207001950 @default.
- W2040382098 hasConceptScore W2040382098C2777359374 @default.
- W2040382098 hasConceptScore W2040382098C2777466164 @default.
- W2040382098 hasConceptScore W2040382098C2777477808 @default.
- W2040382098 hasConceptScore W2040382098C2778793413 @default.
- W2040382098 hasConceptScore W2040382098C2780768313 @default.
- W2040382098 hasConceptScore W2040382098C2781109383 @default.
- W2040382098 hasConceptScore W2040382098C526171541 @default.
- W2040382098 hasConceptScore W2040382098C55493867 @default.
- W2040382098 hasConceptScore W2040382098C62231903 @default.
- W2040382098 hasConceptScore W2040382098C71924100 @default.
- W2040382098 hasConceptScore W2040382098C86803240 @default.
- W2040382098 hasConceptScore W2040382098C87644729 @default.
- W2040382098 hasConceptScore W2040382098C98274493 @default.
- W2040382098 hasIssue "12" @default.
- W2040382098 hasLocation W20403820981 @default.
- W2040382098 hasLocation W20403820982 @default.
- W2040382098 hasOpenAccess W2040382098 @default.
- W2040382098 hasPrimaryLocation W20403820981 @default.
- W2040382098 hasRelatedWork W1811726278 @default.
- W2040382098 hasRelatedWork W2002557173 @default.
- W2040382098 hasRelatedWork W2055277487 @default.
- W2040382098 hasRelatedWork W2064786661 @default.
- W2040382098 hasRelatedWork W2078077965 @default.
- W2040382098 hasRelatedWork W2087543966 @default.
- W2040382098 hasRelatedWork W2090709712 @default.
- W2040382098 hasRelatedWork W2117945043 @default.
- W2040382098 hasRelatedWork W2333545475 @default.
- W2040382098 hasRelatedWork W2399637314 @default.
- W2040382098 hasVolume "16" @default.
- W2040382098 isParatext "false" @default.
- W2040382098 isRetracted "false" @default.
- W2040382098 magId "2040382098" @default.
- W2040382098 workType "article" @default.