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• W2040383569 endingPage "1244" @default.
• W2040383569 startingPage "1238" @default.
• W2040383569 abstract "All species of vertebrates synthesize immunoglobulin molecules, which differ in an number of aspects but also share a few common features responsible for their function, such as the presence of a transmembrane domain in the membrane bound form of the immunoglobulin heavy chain (IgTMD) that ensures communication with the signal transducing Igα-Igβ peptides. We have analyzed the gene sequence encoding the IgTMD of different heavy chain isotypes of very distant species, from shark to mammals. The IgTMD sequences show a high degree of sequence identity and their encoding nucleotide sequences were shown to be subject to purifying selection at most sites. We have built molecular models of seven IgTMDs from different vertebrate species and have investigated the formation of homodimer in a palmitoyl oleoyl phosphatidylcholine (POPC) lipid bilayer by molecular dynamics simulations. We found that the conserved FXXXFXXS/TXXXS motif, never observed to date in protein transmembrane chains, is responsible for the two heavy chains association through two pairs of Phe-Phe hydrophobic interactions and two pairs of Ser/Thr-Ser/Ser hydrogen bonds. This interaction pattern, which stabilizes the dimer conformation in the lipid bilayer, was unique, being different from any other pattern identified in transmembrane helices to date." @default.
• W2040383569 created "2016-06-24" @default.
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• W2040383569 creator A5035401744 @default.
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• W2040383569 date "2010-12-01" @default.
• W2040383569 modified "2023-10-16" @default.
• W2040383569 title "An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane" @default.
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• W2040383569 doi "https://doi.org/10.1016/j.ympev.2010.09.022" @default.
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