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- W2040384100 abstract "Clinical use of the β-lactam cephalosporins has resulted in a number of reports of vitamin K-responsive bleeding abnormalities. The effects of these antibiotics on the activities of vitamin K-dependent enzymes in vitro were therefore assessed. The activity of vitamin K-dependent carboxylase was inhibited by 50% by 6–10 mM cefamandole or structurally analogous cephalosporins. The inhibition was noncompetitive with respect to the pentapeptide substrate, vitamin KH2, and CO2. Vitamin K epoxide reductase was less sensitive to and only partially inhibited by cefamandole and the analogs. The possible physiologic significance of the inhibition of these enzymes in clinical hemorrhagic problems was considered." @default.
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- W2040384100 date "1983-09-01" @default.
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- W2040384100 title "Inhibition of Vitamin K-Dependent Carboxylase in Vitro by Cefamandole and Its Structural Analogs" @default.
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- W2040384100 doi "https://doi.org/10.1093/infdis/148.3.571" @default.
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